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1.A.22.1.9
Large-conductance mechanosensitive channel, MscL

Accession Number:A9WMF7
Protein Name:Large-conductance mechanosensitive channel
Length:133
Molecular Weight:14273.00
Species:Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [288705]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

eggNOG: COG1970
HEGENOM: HOG000226782
Entrez Gene ID: 5822459   
Pfam: PF01741   
KEGG: rsa:RSal33209_1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity

References (1)

[1] “Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor.”  Wiens G.D.et.al.   18723615

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIKGFRDFIL KGNVVDLAVA VVIGAAFGTV VTTLVNNIIM PLIAGIVGKP SFNDVWAFQI 
61:	GSDPANKLLL GAFITVLLNF VIIAAAIYFM VVVPMNHVIA RRNAKLGIKA GEETPDPQIV 
121:	LLTEIRDALK SRS