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1.A.23.1.3
Mini conductance (300 pS) mechanosensitive channel, YjeP or MscM (1107aas; 13 TMSs in a 1 + 12 TMS arrangement).  Encoded in an operon with phosphatidyl serine decarboxylase (Moraes and Reithmeier 2012). Protects against hypoosmotic shock (Edwards et al. 2012).

Accession Number:P39285
Protein Name:Uncharacterized mscS family protein yjeP
Length:1107
Molecular Weight:123968.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions, small molecules

Cross database links:

Genevestigator: P39285
EchoBASE: EB2371
EcoGene: EG12478
eggNOG: COG3264
HEGENOM: HBG678563
Entrez Gene ID: 948676   
Pfam: PF00924   
KEGG: ecj:JW4120    eco:b4159   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Structural characterization of Escherichia coli phosphatidylserine decarboxylase.”  Li Q.-X.et.al.   3042771

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRLIITFLMA WCLSWGAYAA TAPDSKQITQ ELEQAKAAKP AQPEVVEALQ SALNALEERK 
61:	GSLERIKQYQ QVIDNYPKLS ATLRAQLNNM RDEPRSVSPG MSTDALNQEI LQVSSQLLDK 
121:	SRQAQQEQER AREIADSLNQ LPQQQTDARR QLNEIERRLG TLTGNTPLNQ AQNFALQSDS 
181:	ARLKALVDEL ELAQLSANNR QELARLRSEL AEKESQQLDA YLQALRNQLN SQRQLEAERA 
241:	LESTELLAEN SADLPKDIVA QFKINRELSA ALNQQAQRMD LVASQQRQAA SQTLQVRQAL 
301:	NTLREQSQWL GSSNLLGEAL RAQVARLPEM PKPQQLDTEM AQLRVQRLRY EDLLNKQPLL 
361:	RQIHQADGQP LTAEQNRILE AQLRTQRELL NSLLQGGDTL LLELTKLKVS NGQLEDALKE 
421:	VNEATHRYLF WTSDVRPMTI AWPLEIAQDL RRLISLDTFS QLGKASVMML TSKETILPLF 
481:	GALILVGCSI YSRRYFTRFL ERSAAKVGKV TQDHFWLTLR TLFWSILVAS PLPVLWMTLG 
541:	YGLREAWPYP LAVAIGDGVT ATVPLLWVVM ICATFARPNG LFIAHFGWPR ERVSRGMRYY 
601:	LMSIGLIVPL IMALMMFDNL DDREFSGSLG RLCFILICGA LAVVTLSLKK AGIPLYLNKE 
661:	GSGDNITNHM LWNMMIGAPL VAILASAVGY LATAQALLAR LETSVAIWFL LLVVYHVIRR 
721:	WMLIQRRRLA FDRAKHRRAE MLAQRARGEE EAHHHSSPEG AIEVDESEVD LDAISAQSLR 
781:	LVRSILMLIA LLSVIVLWSE IHSAFGFLEN ISLWDVTSTV QGVESLEPIT LGAVLIAILV 
841:	FIITTQLVRN LPALLELAIL QHLDLTPGTG YAITTITKYL LMLIGGLVGF SMIGIEWSKL 
901:	QWLVAALGVG LGFGLQEIFA NFISGLIILF EKPIRIGDTV TIRDLTGSVT KINTRATTIS 
961:	DWDRKEIIVP NKAFITEQFI NWSLSDSVTR VVLTIPAPAD ANSEEVTEIL LTAARRCSLV 
1021:	IDNPAPEVFL VDLQQGIQIF ELRIYAAEMG HRMPLRHEIH QLILAGFHAH GIDMPFPPFQ 
1081:	MRLESLNGKQ TGRTLTSAGK GRQAGSL