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1.A.23.3.2
Mechanosensitive NaCl-inducible RpoS-dependent channel (1,000 pS), YbiO (741 aas; 10TMSs).  Protects agains hypoosmotic shock (Edwards et al. 2012).

Accession Number:P75783
Protein Name:Uncharacterized mscS family protein ybiO
Length:741
Molecular Weight:81904.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules, Cl+, Na+

Cross database links:

Genevestigator: P75783 P75783 P75783
EchoBASE: EB3104 EB3104 EB3104
EcoGene: EG13320 EG13320 EG13320
eggNOG: COG0668 COG0668 COG0668
HEGENOM: HBG466489 HBG466489 HBG466489
DIP: DIP-11435N DIP-11435N DIP-11435N
Entrez Gene ID: 945935   
Pfam: PF00924   
KEGG: ecj:JW5108    eco:b0808    ecj:JW5108    eco:b0808    ecj:JW5108    eco:b0808   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport

References (9)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[5] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[6] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[7] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[8] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[9] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MRWILFILFC LLGAPAHAVS IPGVTTTTTT DSTTEPAPEP DIEQKKAAYG ALADVLDNDT 
61:	SRKELIDQLR TVAATPPAEP VPKIVPPTLV EEQTVLQKVT EVSRHYGEAL SARFGQLYRN 
121:	ITGSPHKPFN PQTFSNALTH FSMLAVLVFG FYWLIRLCAL PLYRKMGQWA RQKNRERSNW 
181:	LQLPAMIIGA FIIDLLLLAL TLFVGQVLSD NLNAGSRTIA FQQSLFLNAF ALIEFFKAVL 
241:	RLIFCPNVAE LRPFTIQDES ARYWSRRLSW LSSLIGYGLI VAVPIISNQV NVQIGALANV 
301:	IIMLCMTVWA LYLIFRNKKE ITQHLLNFAE HSLAFFSLFI RAFALVWHWL ASAYFIVLFF 
361:	FSLFDPGNSL KFMMGATVRS LAIIGIAAFV SGMFSRWLAK TITLSPHTQR NYPELQKRLN 
421:	GWLSAALKTA RILTVCVAVM LLLSAWGLFD FWNWLQNGAG QKTVDILIRI ALILFFSAVG 
481:	WTVLASLIEN RLASDIHGRP LPSARTRTLL TLFRNALAVI ISTITIMIVL SEIGVNIAPL 
541:	LAGAGALGLA ISFGSQTLVK DIITGVFIQF ENGMNTGDLV TIGPLTGTVE RMSIRSVGVR 
601:	QDTGAYHIIP WSSITTFANF VRGIGSVVAN YDVDRHEDAD KANQALKDAV AELMENEEIR 
661:	GLIIGEPNFA GIVGLSNTAF TLRVSFTTLP LKQWTVRFAL DSQVKKHFDL AGVRAPVQTY 
721:	QVLPAPGATP AEPLPPGEPT L