TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.23.4.4
Plant plastid mechanosensitive channel MscS-like-2 (Msl2) (controls plastid organellar morphology, as does Msl3) (Haswell and Meyerowitz, 2006Haswell et al., 2008). It functions as do the bacterial homologues, but is essential for leaf growth, chloroplast integrity and normal starch accumulation (Jensen and Haswell 2012).  msl2 msl3 double mutant seedlings exhibit several hallmarks of drought or environmental osmotic stress, including solute accumulation, elevated levels of the compatible osmolyte proline (Pro), and accumulation of the stress hormone abscisic acid (ABA). Furthermore, msl2 msl3 mutants expressed Pro and ABA metabolism genes in a pattern normally seen under drought or osmotic stress. Pro accumulation in the msl2 msl3 mutant was suppressed by conditions that reduce plastid osmotic stress leading to the conclusion that these channels function like their bacterial homologues (Wilson et al. 2014).

Accession Number:Q56X46
Protein Name:Putative uncharacterized protein At5g10490
Length:673
Molecular Weight:74429.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: Q56X46 Q56X46
eggNOG: COG0668 COG0668
HEGENOM: HBG746763 HBG746763
RefSeq: NP_568230.2   
Entrez Gene ID: 830913   
Pfam: PF00924   
KEGG: ath:AT5G10490   

Gene Ontology

GO:0009507 C:chloroplast
GO:0016020 C:membrane
GO:0009526 C:plastid envelope
GO:0005216 F:ion channel activity
GO:0009657 P:plastid organization
GO:0055085 P:transmembrane transport

References (2)

[1] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
[2] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MALYGTLQLS HSLGLCRNQR FCNPENSAMR RRLHISNGPL SLGVPLGQHG FSNILLSNYL 
61:	RRPICSVPCR TTAFRCHSFS ASGKAIEPAV KAVTVVLTKS HGLMQQFPFV YKLVPAVALL 
121:	VFSLWGLVPF ARQGRNILLN KNDNGWKKSG TYHVMTSYVQ PLLLWLGALF ICRALDPVVL 
181:	PTEASKIVKD RLLNFVRSLS TVLAFAYCLS SLIQQTQKLF SETSNPSDTR NMGFQFAGKA 
241:	LYSAVWVAAV SLFMELLGFS TQKWLTAGGL GTVLITLAGR EILTNFLSSV MIHATRPFVL 
301:	NEWIQTKIEG YEVSGTVEHV GWWSPTIIRG EDREAIHIPN HKFTVNVVRN LTQKTHWRIK 
361:	THLAISHLDV NKINNIVADM RKVLAKNPMV EQQRLHRRVF LENVIPENQA LSILISCFVK 
421:	TSHHEEYLGV KEAILLDLLR VISHHRARLA TPIRTIRKMY TETDVENTPF GESMYGGVTS 
481:	RRPLMLIEPA YKINGEDKSK SQNRAAKPTA EQENKGSNPK SKETSSPDLK ANVKVGESPV 
541:	SDTNKVPEET VAKPVIKAVS KPPTPKDTET SGTEKPKAKR SGGTIKSTKT DETDSSTSSA 
601:	SRSTLEENIV LGVALEGSKR TLPIEEEIHS PPMETDAKEL TGARRSGGNG PLVADKEQKD 
661:	SQSQPNSGAS TEP