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1.A.23.4.5
MscM (YbdG) is a distant member of the MscS family. It displays miniconductance (MscM) activity (Schumann et al., 2010; Edwards et al. 2012).

Accession Number:P0AAT4
Protein Name:Miniconductance mechanosensitive channel
Length:415
Molecular Weight:46603.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate ions, small molecules

Cross database links:

Genevestigator: P0AAT4 P0AAT4
EchoBASE: EB2504 EB2504
EcoGene: EG12620 EG12620
eggNOG: COG0668 COG0668
HEGENOM: HBG664382 HBG664382
Entrez Gene ID: 946243   
Pfam: PF00924   
KEGG: ecj:JW0566    eco:b0577    ecj:JW0566    eco:b0577   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport
GO:0000299 C:integral to membrane of membrane fraction
GO:0008381 F:mechanically-gated ion channel activity
GO:0071470 P:cellular response to osmotic stress

References (10)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12.”  Michael N.P.et.al.   7813889
[5] “YbdG in Escherichia coli is a threshold-setting mechanosensitive channel with MscM activity.”  Schumann U.et.al.   20616037
[6] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[7] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[8] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[9] “Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12.”  Michael N.P.et.al.   7813889
[10] “YbdG in Escherichia coli is a threshold-setting mechanosensitive channel with MscM activity.”  Schumann U.et.al.   20616037

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQDLISQVED LAGIEIDHTT SMVMIFGIIF LTAVVVHIIL HWVVLRTFEK RAIASSRLWL 
61:	QIITQNKLFH RLAFTLQGII VNIQAVFWLQ KGTEAADILT TCAQLWIMMY ALLSVFSLLD 
121:	VILNLAQKFP AASQLPLKGI FQGIKLIGAI LVGILMISLL IGQSPAILIS GLGAMAAVLM 
181:	LVFKDPILGL VAGIQLSAND MLKLGDWLEM PKYGADGAVI DIGLTTVKVR NWDNTITTIP 
241:	TWSLVSDSFK NWSGMSASGG RRIKRSISID VTSIRFLDED EMQRLNKAHL LKPYLTSRHQ 
301:	EINEWNRQQG STESVLNLRR MTNIGTFRAY LNEYLRNHPR IRKDMTLMVR QLAPGDNGLP 
361:	LEIYAFTNTV VWLEYESIQA DIFDHIFAIV EEFGLRLHQS PTGNDIRSLA GAFKQ