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1.A.23.5.1
The cyclic nucleotide-binding MscS homologue, MT2508 (the C-terminal domain is the CAP_ED domain CD00038). It lacks mechanosensitivity but is ligand-gated by cyclic nucleotides (Caldwell et al., 2010).

Accession Number:P71915
Protein Name:MscS homologue, MT2508
Length:481
Molecular Weight:52273.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

HEGENOM: HBG564796
RefSeq: NP_216950.1    NP_336991.1   
Entrez Gene ID: 885885    925815   
Pfam: PF00027    PF00924   
KEGG: mtc:MT2508    mtu:Rv2434c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNLLDSTWFY WAVGIAIGLP AGLIVLTELH NILVRRNSHL ARQASLLRNY LLPLGAVLLL 
61:	LVKASEVPAE DPTVRVLTTA FGFLVLVLLL SLLNATLFQG APQQSWRKRL PAIFVDVARF 
121:	ALIGIGLAVI LSYIWGVRVG GLFAALGVTS VVIGLMLQNS VGQIVSGLFM LFEQPFRIDD 
181:	WLETPTARGR VVEVNWRAVH IDTGSGLQIM PNSMLATTAF TNLSRPAGAH ECSITTTFST 
241:	SDPPDKVCAM LNRAASALPH VKPGVVPATI ARGAAEYRTT VRLTSPADEG PTQATFLRWV 
301:	WYAARREGLH LDEADDEFST AERVESALRT VVGPELRLSS SDQQSLARYA RLVRYGTDEI 
361:	VQHAGVVPMG ITFVIAGSVR LTVTTDDGSV VAIATLKKGT FLGLTALTRQ PDPAGAVALE 
421:	EVTALQIGRE HLEQVVMNKP MLLQELGRVI DERQRKAQQA IRRDLHQSPA AAGEHRGPAR 
481:	R