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1.A.24.1.6
Connexin37 (Cx37). The N-terminus contains an α-helix that is required for channel function (Kyle et al., 2009).

Accession Number:P35212
Protein Name:Gap junction alpha-4 protein
Length:333
Molecular Weight:37414.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: P35212
eggNOG: prNOG11651
RefSeq: NP_002051.2   
Entrez Gene ID: 2701   
Pfam: PF00029    PF10582   
OMIM: 121012  gene
KEGG: hsa:2701   

Gene Ontology

GO:0005922 C:connexon complex
GO:0005887 C:integral to plasma membrane
GO:0007043 P:cell-cell junction assembly

References (7)

[1] “Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.”  Reed K.E.et.al.   7680674
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Human connexin 37 is polymorphic but not mutated in tumours.”  Krutovskikh V.et.al.   8761439
[6] “A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development.”  Boerma M.et.al.   10447790
[7] “Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene.”  Saito T.et.al.   10728596

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 
61:	CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD 
121:	PQVERALAAV ERQMAKISVA EDGRLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT 
181:	MEPVFVCQRA PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELVH LLCRCLSRGM 
241:	RARQGQDAPP TQGTSSDPYT DQVFFYLPVG QGPSSPPCPT YNGLSSSEQN WANLTTEERL 
301:	ASSRPPLFLD PPPQNGQKPP SRPSSSASKK QYV