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1.A.24.2.1
Connexin 47 gap junction (catalyzes intercellular diffusion of neurobiotin, Lucifer yellow and 4',6-diamidino-2-phenylindole; expressed in brain and spinal cord neurons) (Teubner et al., 2001). Possesses sequences between TMSs 2 and 3 and following TMS 4 that differ from these regions in most other connexins.

Accession Number:Q8BQU6
Protein Name:Gap junction alpha-12 protein aka Connexin-47
Length:440
Molecular Weight:47008.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Neurobiotin, Lucfier yellow

Cross database links:

Genevestigator: Q8BQU6
HEGENOM: HBG717760
RefSeq: NP_536702.3    NP_780661.2   
Entrez Gene ID: 118454   
Pfam: PF00029    PF10582   
KEGG: mmu:118454   

Gene Ontology

GO:0005922 C:connexon complex
GO:0016021 C:integral to membrane
GO:0005243 F:gap junction channel activity
GO:0007267 P:cell-cell signaling

References (7)

[1] “Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons.”  Teubner B.et.al.   11160382
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Variable promoter usage and alternative splicing in five mouse connexin genes.”  Anderson C.L.et.al.   15676282
[4] “Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS.”  Odermatt B.et.al.   12805295
[5] “Connexins are critical for normal myelination in the CNS.”  Menichella D.M.et.al.   12843301
[6] “Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain.”  Li X.et.al.   15183511
[7] “Comprehensive identification of phosphorylation sites in postsynaptic density preparations.”  Trinidad J.C.et.al.   16452087

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGESIYSDE QSKFTCNTRQ 
61:	PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH RLARASEQER RRALRRRPGT 
121:	RRLPRAQLPP PPPGWPDTTD LGEAEPILAL EEDEDEEPGA PEGPGEDTEE ERAEDVAAKG 
181:	GGGDGKTVVT PGPAGQHDGR RRIQREGLMR VYVAQLVVRA AFEVAFLVGQ YLLYGFEVPP 
241:	FFACSRQPCP HVVDCFVSRP TEKTVFLLVM YVVSCLCLLL NLCEMAHLGL GSAQDAVRGR 
301:	RGASAAGPGP TPRPPPCAFP AAAAGLACPP DYSLVVRAAE RARAHDQNLA NLALQALRDG 
361:	AAVAAVSADR DSPPCAGLNA TSRGAPRVGG LASGTGSATS GGTVGEQSRP GAQEQLATKP 
421:	RAGSEKGSTG SRDGKATVWI