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1.A.25.1.4
Invertebrate innexin, passover protein (shaking B locus)

Accession Number:P33085
Protein Name:SHAK aka SHAKB aka SHAK-B aka PAS aka CG1321
Length:372
Molecular Weight:44355.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

eggNOG: inNOG05840
RefSeq: NP_001097038.2    NP_001138222.1    NP_523425.2    NP_608410.2    NP_728361.1   
Entrez Gene ID: 33062   
Pfam: PF00876   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-002787-MONOMER   
KEGG: dme:Dmel_CG3435   

Gene Ontology

GO:0005921 C:gap junction
GO:0016021 C:integral to membrane
GO:0005243 F:gap junction channel activity
GO:0009881 F:photoreceptor activity
GO:0016264 P:gap junction assembly
GO:0007630 P:jump response
GO:0007602 P:phototransduction

References (9)

[1] “Analysis of a cDNA from the neurologically active locus shaking-B (Passover) of Drosophila melanogaster.”  Crompton D.E.et.al.   1487155
[2] “Passover: a gene required for synaptic connectivity in the giant fiber system of Drosophila.”  Krishnan S.N.et.al.   8500183
[3] “Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system.”  Crompton D.et.al.   7601305
[4] “Molecular basis of intracistronic complementation in the Passover locus of Drosophila.”  Krishnan S.N.et.al.   7892218
[5] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[6] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[7] “The shaking B gene in Drosophila regulates the number of gap junctions between photoreceptor terminals in the lamina.”  Shimohigashi M.et.al.   9552170
[8] “Drosophila Shaking-B protein forms gap junctions in paired Xenopus oocytes.”  Phelan P.et.al.   9428764
[9] “Nested transcripts of gap junction gene have distinct expression patterns.”  Zhang Z.et.al.   10440730

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLDIFRGLKN LVKVSHVKTD SIVFRLHYSI TVMILMSFSL IITTRQYVGN PIDCVHTKDI 
61:	PEDVLNTYCW IQSTYTLKSL FLKKQGVSVP YPGIGNSDGD PADKKHYKYY QWVCFCLFFQ 
121:	AILFYTPRWL WKSWEGGKIH ALIMDLDIGI CSEAEKKQKK KLLLDYLWEN LRYHNWWAYR 
181:	YYVCELLALI NVIGQMFLMN RFFDGEFITF GLKVIDYMET DQEDRMDPMI YIFPRMTKCT 
241:	FFKYGSSGEV EKHDAICILP LNVVNEKIYI FLWFWFILLT FLTLLTLIYR VVIIFSPRMR 
301:	VYLFRMRFRL VRRDAIEIIV RRSKMGDWFL LYLLGENIDT VIFRDVVQDL ANRLGHNQHH 
361:	RVPGLKGEIQ DA