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1.A.25.1.5
Invertebrate innexin, NSY-5 (INX-19) (Chuang et al., 2007) (establishes left-right neuronal asymmetry) (Oviedo and Levin, 2007)

Accession Number:O61715
Protein Name:Innexin protein 19, isoform a
Length:454
Molecular Weight:52975.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

HEGENOM: HBG389069
RefSeq: NP_490983.2    NP_871864.1   
Entrez Gene ID: 171805   
Pfam: PF00876   
KEGG: cel:T16H5.1   

Gene Ontology

GO:0005921 C:gap junction
GO:0016021 C:integral to membrane
GO:0030154 P:cell differentiation
GO:0007399 P:nervous system development
GO:0040018 P:positive regulation of multicellular organi...

References (3)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “The C. elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.”  Barnes T.M.et.al.   9375655
[3] “An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans.”  Chuang C.-F.et.al.   17512411

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWRTPASTGP LRQDRQMFFH ATLARSFINA LSVRGDDDAV DRLNYYYTPL ILAVCCLVIS 
61:	AKQYGGTPIE CWVNPHSRES MEEYIESYCW IQNTYWIPMY ENVPDDHTAR EEKQIGYYQW 
121:	VPFILIAEAL MFSLPCIFWR LCSFQSGLNI QTLINAACDG QALLDASDRQ KAVEAITTNF 
181:	VDNLDLQSPN GRIRARGWIA RIKFSRFLSG QCLSILHSFT KLLYSMNVVA QFLILNACLK 
241:	SSDFLFFGFQ VLNDIWAGRP WTETGHFPRV TLCDFEVRYL ANLNRYTVQC ALLINIINEK 
301:	VFAFLWCWYM ILAIITTCSF IYWIANSFIH SEKVDYVMKF IQIAESSEFK KLQKFEKDAT 
361:	VERLYTVIAF APHLLDTFVS DFLKSDGVLM LRMISNHAGD MIVVQLVRNL WQEFRERNWR 
421:	EFEEHEEMKD VEMRRIHGGE RIVISNPGQT KSFL