TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.25.1.8
Innexin Inx4 (Innexin-4) (Protein zero population growth)

Accession Number:Q9VRX6
Protein Name:Innexin inx4
Length:367
Molecular Weight:42784.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

eggNOG: NOG81426
DIP: DIP-17426N
Entrez Gene ID: 251414   
Pfam: PF00876   
KEGG: dme:Dmel_CG1012   

Gene Ontology

GO:0005921 C:gap junction
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0055077 F:gap junction hemi-channel activity
GO:0005216 F:ion channel activity
GO:0007281 P:germ cell development

References (5)

[1] “Gap junctions in Drosophila: developmental expression of the entire innexin gene family.”  Stebbings L.A.et.al.   11960713
[2] “A germline-specific gap junction protein required for survival of differentiating early germ cells.”  Tazuke S.I.et.al.   11973283
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[5] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MYAAVKPLSK YLQFKSVHIY DAIFTLHSKV TVALLLACTF LLSSKQYFGD PIQCFGDKDM 
61:	DYVHAFCWIY GAYVSDNVTV TPLRNGAAQC RPDAVSKVVP PENRNYITYY QWVVLVLLLE 
121:	SFVFYMPAFL WKIWEGGRLK HLCDDFHKMA VCKDKSRTHL RVLVNYFSSD YKETHFRYFV 
181:	SYVFCEILNL SISILNFLLL DVFFGGFWGR YRNALLSLYN GDYNQWNIIT MAVFPKCAKC 
241:	EMYKGGPSGS SNIYDYLCLL PLNILNEKIF AFLWIWFILV AMLISLKFLY RLATVLYPGM 
301:	RLQLLRARAR FMPKKHLQVA LRNCSFGDWF VLMRVGNNIS PELFRKLLEE LYEAQSLIKI 
361:	PPGADKI