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1.A.26.1.2
The Mg2+ transporter, MgtE. The crystal structure of the N-terminal hydrophilic domain has been determined to 2.3 Å resolution (Hattori et al., 2007) (>50% identical to 9.A.19.1.1), while the C-terminal transmembrane domain has been determined at 2.2 Å resolution (Takeda et al. 2014). The structure reveals a homoldimer with the channel at the interface of the two subunits.  There's a plug at the cytoplasmic face.  It can bind Mg2+, Mn2+ and Ca2+.

Accession Number:Q5SMG8
Protein Name:Mg2+ transporter MgtE
Length:450
Molecular Weight:50078.00
Species:Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [300852]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+, Mn2+, Ca2+

Cross database links:

eggNOG: COG2239 COG2239
HEGENOM: HBG680933 HBG680933
RefSeq: YP_144326.1   
Entrez Gene ID: 3168925   
Pfam: PF00571    PF01769    PF03448   
BioCyc: TTHE300852:TTHA1060-MONOMER   
KEGG: ttj:TTHA1060    ttj:TTHA1060   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0003824 F:catalytic activity
GO:0008324 F:cation transmembrane transporter activity
GO:0000287 F:magnesium ion binding
GO:0042803 F:protein homodimerization activity
GO:0015693 P:magnesium ion transport
GO:0008152 P:metabolic process
GO:0015095 F:magnesium ion transmembrane transporter activity

References (2)

[1] “Crystal structure of the MgtE Mg(2+) transporter.”  Hattori M.et.al.   17700703
[2] “Crystal structure of the MgtE Mg(2+) transporter.”  Hattori M.et.al.   17700703
Structure:
2YVX   2YVY   2YVZ   2ZY9   4U9L   4U9N   4WIB     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEKLAVSLQ EALQEGDTRA LREVLEEIHP QDLLALWDEL KGEHRYVVLT LLPKAKAAEV 
61:	LSHLSPEEQA EYLKTLPPWR LREILEELSL DDLADALQAV RKEDPAYFQR LKDLLDPRTR 
121:	AEVEALARYE EDEAGGLMTP EYVAVREGMT VEEVLRFLRR AAPDAETIYY IYVVDEKGRL 
181:	KGVLSLRDLI VADPRTRVAE IMNPKVVYVR TDTDQEEVAR LMADYDFTVL PVVDEEGRLV 
241:	GIVTVDDVLD VLEAEATEDI HKLGAVDVPD LVYSEAGPVA LWLARVRWLV ILILTGMVTS 
301:	SILQGFESVL EAVTALAFYV PVLLGTGGNT GNQSATLIIR ALATRDLDLR DWRRVFLKEM 
361:	GVGLLLGLTL SFLLVGKVYW DGHPLLLPVV GVSLVLIVFF ANLVGAMLPF LLRRLGVDPA 
421:	LVSNPLVATL SDVTGLLIYL SVARLLLEAV