TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.26.2.2
Mg2+ transporter, SLC41A2 (11 TMSs with the N-terminus out and the C-terminus in) (Sahni et al. 2007). (63% identical to SLC41A1) See also (Wabakken et al., 2003; Schmitz et al., 2007)

Accession Number:Q96JW4
Protein Name:SLC41A2
Length:573
Molecular Weight:62473.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

Genevestigator: Q96JW4 Q96JW4 Q96JW4
eggNOG: prNOG10271 COG1824 COG1824
HEGENOM: HBG383912 HBG383912 HOG000007017
RefSeq: NP_115524.3   
Entrez Gene ID: 84102   
Pfam: PF01769   
OMIM: 610802  gene
KEGG: hsa:84102    hsa:84102    hsa:84102   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport
GO:0055085 P:transmembrane transport

References (12)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[4] “SLC41A2 encodes a plasma-membrane Mg2+ transporter.”  Sahni J.et.al.   16984228
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[8] “SLC41A2 encodes a plasma-membrane Mg2+ transporter.”  Sahni J.et.al.   16984228
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[12] “SLC41A2 encodes a plasma-membrane Mg2+ transporter.”  Sahni J.et.al.   16984228

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTNSKGRSIT DKTSGGPSSG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY QKNQEDRHKK 
61:	ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH ASSSCSQKYD DYANYNYCDG 
121:	RETSETTAML QDEDISSDGD EDAIVEVTPK LPKESSGIMA LQILVPFLLA GFGTVSAGMV 
181:	LDIVQHWEVF RKVTEVFILV PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN 
241:	LALKQVQATV VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV 
301:	IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP LVGVFFLALT 
361:	PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT TVSDPNLVGI VVYTPVINGI 
421:	GGNLVAIQAS RISTYLHLHS IPGELPDEPK GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH 
481:	LIFLYTIHLM KSGHTSLTII FIVVYLFGAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP 
541:	YLTALGDLLG TALLALSFHF LWLIGDRDGD VGD