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1.A.26.2.3
Solute carrier protein (SLC) 41A3.  The gene is upregulated when mice are given a Mg2+ deficient diet (de Baaij et al. 2013).  SLC41A3 knockout mice develop abnormal locomotor coordination.

Accession Number:Q96GZ6
Protein Name:Solute carrier family 41 member 3
Length:507
Molecular Weight:54767.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

HOG000007017HOG000007017
Genevestigator: Q96GZ6 Q96GZ6 Q96GZ6 Q96GZ6
eggNOG: COG1824 COG1824 COG1824 COG1824
Entrez Gene ID: 54946   
Pfam: PF01769   
KEGG: hsa:54946    hsa:54946    hsa:54946    hsa:54946   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity

References (12)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDGTETRQRR LDSCGKPGEL GLPHPLSTGG LPVASEDGAL RAPESQSVTP KPLETEPSRE 
61:	TTWSIGLQVT VPFMFAGLGL SWAGMLLDYF QHWPVFVEVK DLLTLVPPLV GLKGNLEMTL 
121:	ASRLSTAANT GQIDDPQEQH RVISSNLALI QVQATVVGLL AAVAALLLGV VSREEVDVAK 
181:	VELLCASSVL TAFLAAFALG VLMVCIVIGA RKLGVNPDNI ATPIAASLGD LITLSILALV 
241:	SSFFYRHKDS RYLTPLVCLS FAALTPVWVL IAKQSPPIVK ILKFGWFPII LAMVISSFGG 
301:	LILSKTVSKQ QYKGMAIFTP VICGVGGNLV AIQTSRISTY LHMWSAPGVL PLQMKKFWPN 
361:	PCSTFCTSEI NSMSARVLLL LVVPGHLIFF YIIYLVEGQS VINSQTFVVL YLLAGLIQVT 
421:	ILLYLAEVMV RLTWHQALDP DNHCIPYLTG LGDLLGSSSV GHTAAVPRRC TASPGWGLIQ 
481:	PFICTQHLIV SLLSFYFPFC LLAKTSI