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1.A.27.1.3
FXYD6 regulator of Na,K-ATPase in the ear and taste buds (95 aas; Delprat et al., 2007; Shindo et al., 2011)

Accession Number:Q9H0Q3
Protein Name:FXYD domain-containing ion transport regulator 6
Length:95
Molecular Weight:10542.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate anions

Cross database links:

Genevestigator: Q9H0Q3
eggNOG: prNOG20479
HEGENOM: HBG444253
RefSeq: NP_001158303.1    NP_001158304.1    NP_001158308.1    NP_001158309.1    NP_071286.1   
Entrez Gene ID: 53826   
Pfam: PF02038   
OMIM: 181500  phenotype
603342  phenotype
606683  gene
KEGG: hsa:53826   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport

References (6)

[1] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”  Wiemann S.et.al.   11230166
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia.”  Choudhury K.et.al.   17357072

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELVLVFLCS LLAPMVLASA AEKEKEMDPF HYDYQTLRIG GLVFAVVLFS VGILLILSRR 
61:	CKCSFNQKPR APGDEEAQVE NLITANATEP QKAEN