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1.A.27.1.4
The sterol (dexamethasone, aldosterone) and low NaCl diet-inducible FXYD domain-containing ion transport regulator 4 precursor (Channel inducing factor, CHIF). It is an IsK-like MinK homologue (Attali et al., 1995). It regulates the Na+,K+-ATPase and the KCNQ1 channel protein as well as other ICNQ channels, opening them at all membrane potentials (Jespersen et al. 2006). CHIF as an indirect modulator of several different ion transport mechanisms, consistent with regulation of the Na+-K+-ATPase as the common denominator (Goldschmidt et al. 2004).

Accession Number:Q63113
Protein Name:FXYD domain-containing ion transport regulator 4 aka CHIF
Length:87
Molecular Weight:9084.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate anions

Cross database links:

RefSeq: NP_071783.1   
Entrez Gene ID: 64190   
Pfam: PF02038   
KEGG: rno:64190   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005267 F:potassium channel activity
GO:0005515 F:protein binding
GO:0006811 P:ion transport

References (2)

[1] “A corticosteroid-induced gene expressing an 'IsK-like' K+ channel activity in Xenopus oocytes.”  Attali B.et.al.   7597086
[2] “Cellular localization and regulation of CHIF in kidney and colon.”  Capurro C.et.al.   8843704
Structure:
2JP3     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEGITCAFLL VLAGLPVLEA NGPVDKGSPF YYDWESLQLG GMIFGGLLCI AGIAMALSGK 
61:	CKCRRNHTPS SLPEKVTPLI TPGSAST