TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.27.3.1
FXYD5 regulator of Na,K+-ATPase and ion channel activities of 178 aas and 1 C-terminal TMS.  FXYD5 interacts directly with the Na+,K+-ATPase via their TMSs to affect the Vmax of the latter, and residues involved have been identified (Lubarski et al. 2007).

Accession Number:Q96DB9
Protein Name:Dysadherin aka FxyD5
Length:178
Molecular Weight:19453.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate ions

Cross database links:

Genevestigator: Q96DB9
eggNOG: prNOG15182
RefSeq: NP_001158077.1    NP_054883.3    NP_659003.1   
Entrez Gene ID: 53827   
Pfam: PF02038   
OMIM: 606669  gene
KEGG: hsa:53827   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0003779 F:actin binding
GO:0045296 F:cadherin binding
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0030033 P:microvillus assembly
GO:0046588 P:negative regulation of calcium-dependent ce...

References (6)

[1] “A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins.”  Omasa T.et.al.   11342114
[2] “Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.”  Ino Y.et.al.   11756660
[3] “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.”  Zhang Q.-H.et.al.   11042152
[4] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[5] “The DNA sequence and biology of human chromosome 19.”  Grimwood J.et.al.   15057824
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV YTELQPTSPT 
61:	PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP TDDTTTLSER PSPSTDVQTD 
121:	PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA AVLFITGIII LTSGKCRQLS RLCRNHCR