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1.A.28.1.1
Kidney vasopressin regulated urea transporter, UT-A2 (splice variant of UT-A1)

Accession Number:Q62668
Protein Name:UT-A2 aka SLC14A2 aka UT2
Length:929
Molecular Weight:101896.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:20
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate Urea

Cross database links:

Genevestigator: Q62668
eggNOG: roNOG13093
RefSeq: NP_001103740.1    NP_062220.2    NP_808877.2   
Entrez Gene ID: 54302   
Pfam: PF03253   
KEGG: rno:54302   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0015204 F:urea transmembrane transporter activity
GO:0009414 P:response to water deprivation
GO:0015840 P:urea transport

References (7)

[1] “Cloning and regulation of expression of the rat kidney urea transporter (rUT2).”  Smith C.P.et.al.   7657826
[2] “Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts.”  Shayakul C.et.al.   8958221
[3] “Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4.”  Karakashian A.et.al.   10215321
[4] “Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts.”  Shayakul C.et.al.   11181411
[5] “Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts.”  Klein J.D.et.al.   16959825
[6] “Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.”  Hoffert J.D.et.al.   16641100
[7] “The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.”  Mistry A.C.et.al.   17702749

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDHPLKEMS DNNRSPPLPE PLSSRYKLYE SELSSPTWPS SSQDTHPALP LLEMPEEKDL 
61:	RSSDEDSHIV KIEKPNERSK RRESELPRRA SAGRGAFSLF QAVSYLTGDM KECKNWLKDK 
121:	PLVLQFLDWV LRGAAQVMFV NNPLSGLIIF IGLLIQNPWW TIAGALGTVV STLAALALSQ 
181:	DRSAIASGLH GYNGMLVGLL VAVFSEKLDY YWWLLFPVTF ASMACPVISS ALSTVFAKWD 
241:	LPVFTLPFNI ALTLYLAATG HYNLFFPTTL VKPASSAPNI TWSEIEMPLL LQTIPVGVGQ 
301:	VYGCDNPWTG GVILVALFIS SPLICLHAAI GSIVGLLAAL TVATPFETIY TGLWSYNCVL 
361:	SCVAIGGMFY VLTWQTHLLA LVCALFCAYT GAALSNMMAV VGVPPGTWAF CLSTLTFLLL 
421:	TSNNPGIHKL PLSKVTYPEA NRIYFLTAKR SDEQKPPNGG GGEQSHGGGQ RKAEEGSETV 
481:	FPRRKSVFHI EWSSIRRRSK VFGKSEHQER QTKEPLPYLY RKPTVELLDL NTMEESSEIK 
541:	VETNTTRTTW IQSSMIAGGK RVSKALSYIT GEMKECGEGL KDKSPVFQFL DWVLRGTSQV 
601:	MFVNNPLSGI LIVLGLFVQN PWWAISGCLG TIMSTLTALI LSQDKSAIAA GLHGYNGVLV 
661:	GLLMAVFSDK GNYYWWLLLP VIVMSMTCPI LSSALSTVFS KWDLPVFTLP FNIAVTLYLA 
721:	ATGHYNLFFP TKLLQPAVTT PNITWSDVQV PLLLRAIPVG IGQVYGCDNP WTGGIFLVAL 
781:	FVSSPLICLH AAIGSTIGML AALSIATPFD SIYFGLCGFN STLACIAIGG MFYVITWQTH 
841:	LLAIACALFA AYLGAALANM LSVFGLPPCT WPFCLSALTF LLLTTNNPGI YKLPLSKVTY 
901:	PEANRIYFLS QEKNRRASMI TKYQAYDVS