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1.A.28.1.3
Kidney urea transporter, UT-A1 (mediates transepithelial urea transport in the inner medullary collecting duct for urinary concentration. Interacts with the C-terminus of Snapin (O95295) and SNARE-associated protein) (Mistry et al., 2007). Also transports formamide, acetamide, methylurea, methylformamide, ammonium carbamate, and acrylamide, and possibly dimethylurea and thiourea as well (Zhao et al., 2007). Mutation of the N-linked glycosylation sites reduces urea flux by reducing the UT-A1 half-life and decreasing its accumulation in the apical plasma membrane. The related erythrocyte urea transporter, UTB (UT-B; TC# 1.A.28.1.5) has been reviewed (Bagnasco, 2006). Mutation of the N-linked glycosylation sites reduces urea flux by reducing the UT-A1 half-life and decreasing its accumulation in the apical plasma membrane (Chen et al. 2006). In vivo, inner medullary collecting duct cells may thus regulate urea uptake by altering UT-A1 glycosylation in response to AVP stimulation.

Accession Number:P70633
Protein Name:UT-A1 aka UT11
Length:414
Molecular Weight:45214.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate Urea

Cross database links:

Genevestigator: P70633
eggNOG: roNOG04220
RefSeq: NP_062219.2   
Entrez Gene ID: 54301   
Pfam: PF03253   
KEGG: rno:54301   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015204 F:urea transmembrane transporter activity
GO:0015840 P:urea transport

References (1)

[1] “Cloning and functional characterization of a rat urea transporter: expression in the brain.”  Couriaud C.et.al.   8982255

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMEDIPTMV KVDRGESQIL SCRGRRCGLK VLGYVTGDMK EFANWLKDKP VVLQFMDWIL 
61:	RGISQVVFVS NPISGILILA GLLVQNPWWA LCGCVGTVVS TLTALLLSQD RSAITAGLQG 
121:	YNATLVGILM AVFSDKGDYF WWLIFPVSAM SMTCPVFSSA LSSLFSKWDL PVFTLPFNMA 
181:	LSLYLPATGH YNTFFPSKLF MPVSSVPNIT WSELSALELL KSLPVGVGQI YGCDNPWTGA 
241:	IFLCAILLSS PLMCLHAAIG SLLGVIAGLS LAAPFKDIFS GLWGFNSSLA CIAIGGMFMA 
301:	LTWQTHLLAL ACALFTAYFG ACMTHLMAAV HLPACTWSFC LATLLFLLLT TENPNIYRMP 
361:	LSKVTYSEEN RIFYLQNKKR VVDSVCVHVC VCGCMCILPV CVLLHVYLCV SVSS