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1.A.28.1.4
THe Urea transporter channel protein of 337 aas and 11 TMSs. The 3-d structure (2.3 Å resolution) is available (Levin et al., 2009).  Urea binding and flux as well as dimethylurea (DMU) transport have been modeled (Zhang et al. 2017).

Accession Number:A1VEP3
Protein Name:Urea transporter
Length:337
Molecular Weight:35757.00
Species:Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [391774]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Urea, dimethylurea

Cross database links:

eggNOG: COG4413
HEGENOM: HBG583034
RefSeq: YP_967336.1   
Entrez Gene ID: 4663590   
Pfam: PF03253   
KEGG: dvl:Dvul_1892   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015204 F:urea transmembrane transporter activity
GO:0015840 P:urea transport
Structure:
3k3f   3m6e     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MFGEQLLKNP LIEFCDSVCR GCGQVMFQNN TVTGLLFFAG IFYNSTTLGV CAVLGTAAST 
61:	LTAQLLGVDK PLVRAGLFGF NGTLAGIALP FFFNYEPAML GYVALNGAFT TIIMASLLNF 
121:	LGKWGVPALT APFVLATWLL MFGVYKLSLF HPGALIAPAL PSVAGLADMG TVTGRTFMEG 
181:	LFKGVGEVMF QDNIVTGVIF VVAILVNSRI SALFAVIGSL VGLCTALIMH SPETPVRLGL 
241:	YGFNSVLCGI AMGGIFFYLN IRTFLYALGC MVLGAIATGA FSVLLSPIGM PALTWPFIVV 
301:	TWLFLFAGSM FRNIAQVPTE KAGTPEDNLR SLAIGSR