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1.A.28.1.5
Urea transporter 1 or UT-B1 (Solute carrier family 14 member 1; Urea transporter of the erythrocyte) (Bagnasco 2006).  A phenylphthalazine compound, PU1424, is a potent UT-B inhibitor, inhibiting human and mouse UT-B-mediated urea transport with IC50 values of 0.02 and 0.69 mumol/L, respectively, and exerted 100% UT-B inhibition at high concentrations (Ran et al. 2016). UT-B catalyzes transmembrane water transport which can be ued as a reporter system (Schilling et al. 2016).  Knocking out both UT1 and UT2 increases urine output 3.5-fold and lowers urine osmolarity (Jiang et al. 2016). The double knockout also lowered blood pressure and promoted maturation of the male reproductive system. Thus, functional deficiency of all UTs causes a urea-selective urine-concentrating defect with few physiological abnormalities in extrarenal organs (Jiang et al. 2016).

Accession Number:Q13336
Protein Name:Urea transporter 1
Length:389
Molecular Weight:42528.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Urea

Cross database links:

Genevestigator: Q13336
eggNOG: COG4413
HEGENOM: HOG000065705
Entrez Gene ID: 6563   
Pfam: PF03253   
KEGG: hsa:6563   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015204 F:urea transmembrane transporter activity
GO:0005372 F:water transmembrane transporter activity

References (10)

[1] “Cloning and functional expression of a urea transporter from human bone marrow cells.”  Olives B.et.al.   7989337
[2] “RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.”  Davey S.et.al.   8573795
[3] “The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility.”  Olives B.et.al.   9215669
[4] “At physiological expression levels, the Kidd blood group/urea transporter protein is not a water channel.”  Sidoux-Walter F.et.al.   10514515
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Erythroid urea transporter deficiency due to novel JKnull alleles.”  Wester E.S.et.al.   18028269
[8] “Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns.”  Sidoux-Walter F.et.al.   10942407
[9] “Genomic characterization of the Kidd blood group gene: different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns.”  Irshaid N.M.et.al.   10644814
[10] “Two novel Jk(null) alleles derived from 222C>A in Exon 5 and 896G>A in Exon 9 of the JK gene.”  Liu H.M.et.al.   18980618

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEDSPTMVRV DSPTMVRGEN QVSPCQGRRC FPKALGYVTG DMKELANQLK DKPVVLQFID 
61:	WILRGISQVV FVNNPVSGIL ILVGLLVQNP WWALTGWLGT VVSTLMALLL SQDRSLIASG 
121:	LYGYNATLVG VLMAVFSDKG DYFWWLLLPV CAMSMTCPIF SSALNSMLSK WDLPVFTLPF 
181:	NMALSMYLSA TGHYNPFFPA KLVIPITTAP NISWSDLSAL ELLKSIPVGV GQIYGCDNPW 
241:	TGGIFLGAIL LSSPLMCLHA AIGSLLGIAA GLSLSAPFED IYFGLWGFNS SLACIAMGGM 
301:	FMALTWQTHL LALGCALFTA YLGVGMANFM AEVGLPACTW PFCLATLLFL IMTTKNSNIY 
361:	KMPLSKVTYP EENRIFYLQA KKRMVESPL