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1.A.3.1.3
The Ryanodine Receptor homologue, RyRi (5,101 aas; 77% identical to the A gambiae RyR) of the aphid, Myzus persicae, is the tartet of diamide insecticides and is made without alternative splicing (Troczka et al. 2015). The almost identical well characterized orthologue from the oriential fruit fly, Bactrocera dorsalis also has its 6 TMSs C-terminal (Yuan et al. 2014).

Accession Number:Q7PMK5
Protein Name:AGAP010750-PA
Length:5109
Molecular Weight:577541.00
Species:Anopheles gambiae (African malaria mosquito) [7165]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Plastid1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: inNOG07732
HEGENOM: HBG315203
RefSeq: XP_318561.3   
Entrez Gene ID: 1278919   
Pfam: PF08709    PF00520    PF02815    PF08454    PF06459    PF01365    PF02026    PF00622   
KEGG: aga:AgaP_AGAP01   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005509 F:calcium ion binding
GO:0005219 F:ryanodine-sensitive calcium-release channel...
GO:0006816 P:calcium ion transport
GO:0006874 P:cellular calcium ion homeostasis
GO:0055085 P:transmembrane transport

References (1)

[1] “The genome sequence of the malaria mosquito Anopheles gambiae.”  Holt R.A.et.al.   12364791

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS 
61:	QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS 
121:	SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE 
181:	NDLSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWSLDSG 
241:	QNIVVYEGGS VMSQARSLWR LELARTKWAG GFINWSHPMR IRHLTTGRYL GVNENNELIL 
301:	MSRDQATTSQ TAFVLRLEKD DQKVVLEDKD LEIIGAPIIK YGDSTVIMQH YESGLWVSYK 
361:	SYETKKKGVG KVEEKQAILH EEGKMDDGLD FSRSQEEESR TARVIRKCSS LFTKFISGLE 
421:	TLQENRRHSI FLQTVNLGEM VMCLEDLINY FAQPEDDMEH EEKQNRLRAL RNRQDLFQEE 
481:	GVLNLILEAI DKINVISSQG FLASFLASDE SGQSWDMISG YLYQLLAAII KGNHTNCAQF 
541:	ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD 
601:	PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTG LVDHVASIRP NIFVGRVEGS 
661:	AIYQKWYFEV TMDHIEQMTH MTPHLRIGWA NTAGYVPYPG GGEKWGGNGV GDDLFSYGFD 
721:	GVYFWSAGRR TCVVPREVTE PFIKKGDVIG CTLDLSVPVI RFTFNGEPVQ GCFTDFNLDG 
781:	MFFPVMSCSS KLSCRFLFGG DNGRLKFNPP PGFSPLVQCL MPHQNLSLDP CFYFGNLNKN 
841:	VLAGPWLVED DSAFVPKPVD TSIVTLPSSV ETIKDKLAEN IHEMWALNKI EAGWTWGERR 
901:	DDVYRIHPCL TSFEKLPAAE KRYDCQLAVQ TLKTILALGY YISMDKPPAR IRPIRLPNDP 
961:	YMQGNGYKPA PLDLSAAVLT PKMEELVDQL AENTHNLWAK ERIQQGWTYG LNEDSENLRS 
1021:	PHLVPYSKVD EAIKKANRDT ASETVRTLLI YGYNLDPPTG EANEALAAEA LRQKFAAYRT 
1081:	YRVERTYAVT SGKWYFEFEV LTAGPMRVGW ARADCNPGTM LGSDDASWAF DGYNEEKVSG 
1141:	GATESFGKQW VPGDIVGVFL DLVDHTISFS LNGELLMDAL GGETTFADVN APDGVGFVPA 
1201:	CTIGIGQKAR VVYGQDVDSL KWFTTCGLQE GYEPFCVNMK RPVTHWYTKD QPIFENTDEI 
1261:	PECKIDVTRI PGGADTPPCM KISHNTFETM EKANWEFLRL SLPVTCANTF ITEQEKMRRW 
1321:	EEIRIRQHRL MTEVDHSAPA HFDHIMRSGF TMNDIKGLHR NYSEDAAEAD EMMRNGPRRP 
1381:	SRHQGRGGLS PPGIEINGEA TSDGELNAYS DNELEGGDDR KKRGRSPFRL FGKKRDQSKD 
1441:	KLKDRRTPEP EPRKSNLKVT QRGQATRMSN SDLRAQAPLT PERKGMGSPQ VESFGNEVYD 
1501:	ADCLRLINEY FYGVRIFPGQ DPTHVYVGWV TTQYHVHSKE FSQNKVRHAA IYVEDENEKT 
1561:	IEIVNRQSCY MVRADELFNE VTQDSSGKGA SQGMFVGCFV DTATGTIRFT CEGKETSHVF 
1621:	LMEPDTKLFP AIFVEATSKE ILQIELGRTP TTLPLSAAVL PTSDKHINPQ FPPRLKVQCL 
1681:	KPHQWARVPN TALQVHALKL SDIRGWSMLC EDPVSMLALH IPEEDRCIDI LELIEIDRLL 
1741:	QFHAHTLTLY SALCYQSNYR AAHALCSHVD QKQLLYAIQS EYMSGPLRLG FYDLLISLHL 
1801:	ESHATTMEVC KNEYIIPLGS ELRELYIDPE MCHSLRSLQT LSVRPEMNMT EIAPTPSQSN 
1861:	MPTIVAPDSS SEPIPAIDSL YSPRFPLEVV REFVMSALQE AVQINQVHNR DPIGGSNENL 
1921:	FLPLIKLIDR LLLVGVITNE DVEKLLIMID PETWDPSFEK EGRDEHRKGL LTMKMAEGAK 
1981:	LQMCYLLHHL YDVQLRHRVE SIIAFAHNYV GDLQQDQLRR YIEIKQSDLP SAVAAKKTRE 
2041:	FRCPPREQMN AILGYKNLEE DDLENASCGP ELRNRLIEFH EKLMGKVSLN ALQEPEEPEA 
2101:	DKLEEGRPGA MKKLYNFINA VKELEEDPKE PVEEEKKTPE EVFRKVLIKQ LVSWAEESQI 
2161:	ENPKLVREMF GLLVRQYDTI GELIKALNKT YVINSKTKGD VANMWIGLSQ IRALLPVQMS 
2221:	QEEEELMRKR LWKLVNNHTF FQHPDLIRIL RVHENVMAVM MNTLGRRAQA QSDAPVQTAD 
2281:	GEESAPKEKD TSHQMVVACC RFLCYFCRTG RMNQKAMFDH FDFLLENSNI LLSRPSLRGS 
2341:	TPLDVAYSSL MENTELALAL REHYLEKIAI YLSRCGLQSN SELIERGYPD LGWDPVEGER 
2401:	YLDFLRFCVW VNGESVEENA NLVIRLLIRR PECLGPALRG EGEGLLKAIV DANKMSERIS 
2461:	ERRKMQDEAE GTITGLNFSH PLPEGDDDED YIDTGAAILC FYCTLVDLLG RCAPDAAVIE 
2521:	QGKNESLRAR AILRSLVPLE DLQGVLSLKF TLTNPALGED RPKSDMPSGL VPGHKQSIVL 
2581:	FLERVYGIET QELFYRLLED AFLPDLRAAT MLDRSDGSES DMALSMNRYI GNSILPLLIK 
2641:	HSKFYNEAEN YASLLDATLH TVYRMSKNRM LTKGQREAVS DFLVALTSAM HPAMLLKLLR 
2701:	KLTIDVSKLS EYTTVALRLL TLHYERCAKY YGTTGGGQAS QFGASSDEEK RLTMLLFSNI 
2761:	FDSLSNMDYD PELFGKALPC LIAIGCALPP DYSLSKNSDD DLYGKPTGGG PDQPHYNPQP 
2821:	IDTTAVQLTN DLNQIVQKFS EHYHDAWASR KLENGWTYGD QWSDANKTHP RLKPYNTLSE 
2881:	YERERYREPV RESLKALLAL HWRIEHSEGD VPLSNRGSMR RQSKPNLELQ GDTGSPFNYN 
2941:	PHPVDMTNLT LSREMQNMAE RLAENSHDIW AKKKNEELDQ CGGAIHAQLV PYDLLTDKEK 
3001:	RKDRERSQEF LKYLQYQGLK LHKPSRGQTE EPGMSTAAIE LRFAYSLLEK LISYSDRATI 
3061:	NMKLLKPSST FSRRSSFKTC SRDIKFFSKV VLPLMEKYFS SNRNYFIAIA TATNNVGAAS 
3121:	LKEKEMVAGL FCKLASLLRH RLAAFGADVR ITVRCLQVLV KSIDAKSLVK NCPEFIRTSM 
3181:	LTFFNNTADD LGQTIVNLTD GKYDRLRGTH LKTSTSLAYV NQVILPVLTS LFDHLAACDY 
3241:	GSDLLLDEIQ VASYKILSAL YTLGTDTSLT RDRKYLKTEL ERHKPALGSC LGAFSSCFPV 
3301:	AFLEPHANKH NPFSLLNRIA DTSLEAQDIM SKMESCMPTL ESILSEVDQF VESEKTYQEA 
3361:	QHIIDVILPL LCSYLPFWWN QGPDNVSPQS GNHVTMVTAD HMNHLLKNVL KMIRKNIANE 
3421:	NAPWMTRIAT YTQQIIINSS EELLKDVFLP LAERVKKRCD SMFHKEESLR GFLKSSTDDT 
3481:	SQIEAQIQED WQLLVRDIYS FYPLLIKYVD LQRNHWLKDN VAEAEELYNY VAEIFNVWSK 
3541:	SQYFLKEEQN FISANEIDNM TLIMPTATRR SAAVSGDMPA SGGKVKKKKR SRDKKRDKDK 
3601:	EIQSSLMVAC LKRLLPVGLN LFAGKEQELV QHCKDRYLKK MPEYEVIEFA RTQLTLPDKL 
3661:	DPADEMSWQH YLYSKLGKKE QIVQDTLEKS DKKPENKIED TVERIVAMAK VLYGLHMIDH 
3721:	PQQQSKNVYR SCVSIQRKRA VIACFRQVSL HSLPRHRACN IFARSYSELW LEDENTGQEV 
3781:	MIEDLTQTFE DAEKKKKDEE EEEGKPDPLT QLVTTFCRGA MTERSGALQE DPLYMSYASI 
3841:	VARSCGEEEE EGGDEEEGAG EDEGGASIHE QEMEKQKLLF HQARLANRGV AEMVLLHISA 
3901:	SKGVPSEMVM RTLELGIAVL RGGNIDIQMG MLNHLKEKKD VGFFTSIAGL MNSCSVLDLD 
3961:	AFERNTKAEG LGVGSDGAAG EKNMHDAEFT CALFRFIQLT CEGHNLDWQN YLRTQAGNTT 
4021:	TVNVVICTVD YLLRLQESIM DFYWHYSSKE LIDPAGKANF FKAIGVASQV FNTLTEVIQG 
4081:	PCTQNQQALA HSRLWDAVGG FLFLFSHMQD KLSKHSSQVD LLKELLNLQK DMITMMLSML 
4141:	EGNVVNGTIG KQMVDTLVES ASNVELILKY FDMFLKLKDL TSTPSFMEID SNGDGWIMPK 
4201:	DFREKMEQQK SYTPEEIDFL LACCETNHDG KIDYIGFVDR FHEPAKEIGF NLAVLLTNLS 
4261:	EHMPNEPRLA RFLETAGSVL NYFESFLGRI EIMGSSKRIE RVYFEIKEAN IEQWEKPQIK 
4321:	ESKRAFFYSI VTEGGDKEKL EAFVNFCEDA IFEMTHASGL MASDDDGGTV RRDQAFTYIS 
4381:	EEEEERAARD PIKRTIQAVK DGLSYSMYMI SPSNIKHQIT VLQSKSFPEI IVGFFKMIFY 
4441:	AFYYSGFGVS VVIKYLVNIL MSLMRGPAQE EEEPIPEAEP SLRALPPLPL EEPPGTVQAF 
4501:	GLDISKEENG QYRMAPHESP ALSPSSSIEE TGESSPEDGA AELTGEGVPP GEQMTLVDLL 
4561:	GGEAAKRAAQ ERTEAQKAQE ATLASIEAES KKASTETKEP AAVHQIDFSK YTKKCVSYLA 
4621:	RNFYNLKYVA LVLAFCINFM LLFYKVTTLG DDEDGEGGSG ESLMGLGSGL GSGLGILETG 
4681:	SGGGEGGSGD GEGEEEDPPE KVHVDEDFFY MEHVLRIAAI LHSLVSLCML IAYYHLKVPL 
4741:	AIFKREKEIA RRLEFDGLFI AEQPEDDDIK SHWDKLVISA KTFPVNYWDK FVKKKVRQKY 
4801:	SETYDFDSIS NLLGMEKTAF AAQEANEGGG FFHFITNIDW RYQIWKAGVT ITDNSFLYSL 
4861:	WYFSFSVMGN FNQFFFAAHL LDVAVGFKTL RTILQSVTHN GKQLVLTVML LTIIVYIYTV 
4921:	IAFNFFRKFY VQEDDDGEEG DRKCHDMATC FVFHLYKGVR AGGGIGDEIG DPDGDEYEVY 
4981:	RILFDITFFF FVIVILLAII QGLIIDAFGE LRDQLESVKE DMESNCFICG IGKDYFDKVP 
5041:	HGFDTHVAQE HNLANYMFFL MHLINKPDTE YTGQETYVWN MYQQRCWDFF PVGDCFRKQY 
5101:	EDELGGGGS