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1.A.3.1.5
Ryanodine receptor (RyR) of 5127 aas and 6 TMSs. Intracellular calcium channel that is required for proper muscle function during embryonic development and may be essential for excitation-contraction coupling in larval body wall muscles. Mediates general anaesthesia by halothane (Gao et al. 2013) and confers sensitivity to diamide insecticides (Tao et al. 2013).

Accession Number:Q24498
Protein Name:Ryanodine receptor
Length:5127
Molecular Weight:581012.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Sarcoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI ADKNVPPDLS 
61:	QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHHNS DMYLACLSTS 
121:	SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE 
181:	NEQSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG 
241:	QNIVIYEGGV VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL 
301:	VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH CETSLWLSYK 
361:	SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK TARVIRKCSS LFTQFITALE 
421:	TLQSNRRHSI FFQKVNLNEM VMCLEDLINY FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE 
481:	GVLNLILEAI DKINIITSQG FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF 
541:	ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD 
601:	PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP NIFVGRVDGS 
661:	SMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTSGYVPYPG GGKKWGGNGV GDDLYSFGFD 
721:	GAFLWTGGRK TLVVDALPEE PFIRKGDVIG VAIDLSVPII TFTFNGVKVR GSFRDFNLDG 
781:	MFFPVMSCSS KLSCRFLFGG DHGRLKFAPP MGFSALVQCL MPQQILSLDP CFYFGNLAKN 
841:	VLAGPWLIED DTAFVPKPVD TTGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR 
901:	DDYHRIHPCL THFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR IRPVRLPNEI 
961:	FMQGNGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR ERIQQGWTYG LNEDSENHRS 
1021:	PHLVPYAKVD EAIKKANRDT ASETVRTLLV YGYVLDPPTG EGTEALLAEA QRLKFAGFRT 
1081:	YRVERNYAVT SGKWYFEFEV LTSGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNVTKMHA 
1141:	GSIEHFGVRY EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC 
1201:	TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ PIFENTEEMP 
1261:	DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS LPVTCMGEFI SEQEKARRWD 
1321:	EIKNRQYRLM REAEIAAQMQ VQTQAAHMDH MLKGGFNMND IKGLTRNFDE HADAEADHMM 
1381:	RGPNRPPRKG SLTRNITFET DMSAALDEMQ RSTSVLDMNG LGEEMDDKKK RGRSPFKFFS 
1441:	KKSRDQSREK MGARTLDTSL ERRNTVAHGR NVVNQQMTTR APTLRLNNAE IPPSPVPQGP 
1501:	KQLSGSNLGQ QPVETSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG WVTTQYHLHS 
1561:	REFNKNKVRR GSVYIEDDYE MAIERIDRQS CYVVRADELF NEVTQDASGK GASQGMFVGC 
1621:	FVDTATGIIR FTCEGKDTSH RWMMEPDTKL FPAIFVEATS KEILQIELGR TPTTLPLSAA 
1681:	VLPTSDKHIN PQSPPRLKVQ CLRPHQWARV PNTALQVHAL KLSDVRGWSM LCEDPVSMLA 
1741:	LHIPEEDRCI DILELIEMDK LLSFHAHSLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI 
1801:	RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GAELKELYSD EEMQHSLRSL 
1861:	VTESVRPQLR MTEITPPVIA TSSMPSVSSE PIPDIDQLYS PKFPLEVVRQ FVMEALKDAV 
1921:	EINQVHNRDP IGWTNENLFL PLIKLTDRLL LVGVLTDEDV QRLLVMIDPE TWDQAFEREG 
1981:	KDEHRKGLLT MKMAEGAKLQ MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI 
2041:	EIKQSDLPSA VAAKKTKEFR CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS 
2101:	LMQKVSLNAL QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE EPEKKTPEEV 
2161:	FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE LVRALEKTYV INTRARDDVA 
2221:	EMWVGLSQIR ALLPVQMSQE EEELMRKRLW KLVNNATFFQ HPDLIRILRV HENVMAVMMN 
2281:	TLGRRAQAQS DAPTQSEVAE GAPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD 
2341:	FLLDNANILL ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE 
2401:	LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG 
2461:	EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL PEGEEDEDYI DTGAAILNFY 
2521:	CTLVDLLGRC APDASVIEQG KNESLRARAI LRSLVPLEDL QGVLSLKFTL SQTAPGEEKP 
2581:	KSDMPSGLLP NNKQSIVLFL ERVYGIEAQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM 
2641:	ALAMNRYIGN SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF 
2701:	LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG STQGQGSYGA 
2761:	SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI GCALPPDYSL SKNTDEDYYG 
2821:	RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL VQKFSEHYHD AWASRRLEGG WTYGDIRSDN 
2881:	DRKHPRLKPY NMLSEYERER YRDPVRECLK GLLAIGWTVE HSEVEVALNH RGSTRRQSKP 
2941:	QINEFQNEGS PFNYNPHPVD MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELNGCGGVI 
3001:	HPQLVPYDLL TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA TQAAVELRFS 
3061:	YSLLEKLIQY LDRATINMKL LKPSTTFSRR SSFKTATRDI KFFSKVVLPL MEKYFSTHRN 
3121:	YFIAIATATN NIGAASLKEK EMVASIFCKL AALLRNRLSA FGPDVRITVR CLQVLVKGID 
3181:	ARTLTKNCPE FIRTSMLTFF NQTSDDLGNT ILNLQDGKYS HLRGTHLKTS TSLGYVNQVV 
3241:	LPVLTAMFDH LAACDYGSDL LLDEIQVASY KILAALYHLG TDGTLTHDRK YLKTEIERHR 
3301:	PALGSCLGAY SSCFPVAFLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME SCMPNLETIL 
3361:	AEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD NVSPTSGNHV TMVTADHMNP 
3421:	LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ IIINTSEELL KDPFLPLAER VKKRTENMLH 
3481:	KEDSMRGFIK SATDDTSQVE TQLQEDWNLL VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA 
3541:	EELYNHVAEI FNIWSKSQYF LKEEQNFISA NEIDNMALIM PTATRRSAIS EGAPAVGGKV 
3601:	KKKKKNRDKK RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD RYLKKMPEYD 
3661:	VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEEPVDE QALEKANVNS NEKGKDKTQE 
3721:	TVDRIVAMAK VLFGLHMIDH PQQQSKNVYR SVVSIQRKRA VIACFRQTSL HSLPRHRACN 
3781:	IFARSYYEQW LQEENVGQEV MVEDLTQTFE DSEKSKKEGE ETDSKPDPLT QLVTTFCRGA 
3841:	MTERSGALQE DLLYMSYAQI AAKSTGKEEE EGGDEEGGEG GEEGEGTSIH EQEMEKQKLL 
3901:	FHQARLSNRG VAEMVLLHIS ASKGIPSEMV MTTLNLGIAI LRGGNIDIQM GMLNHLKEKK 
3961:	DVGFFTSIAG LMNSCSVLDL DAFERNTKAE GLGVGSEGAA GEKNMHDAEF TCALFRFIQL 
4021:	TCEGHNLEWQ NYLRTQAGNT TTVNVVICTV DYLLRLQESI MDFYWHYSSK EIIDPAGKAN 
4081:	FFKAIEVASQ VFNTLTEVIQ GPCTLNQQAL AHSRLWDAVG GFLFLFSHMQ DKLSKHSSQV 
4141:	DLLKELLNLQ KDMITMMLSM LEGNVVNGTI GKQMVDTLVE SASNVELILK YFDMFLKLAD 
4201:	LIESPSFHEV DMKNEGWVTP KDFREKMEQS KNYTPEEMDF LLACCERNHE GKIDYRAFVE 
4261:	HFHEPSKEIG FNLAVLLTNL SEHMPNEPRL ARFLETAGSV LNYFEPFLGR IEILGSSKRI 
4321:	ERVYFEIKDS NIEQWEKPQI RESKRAFFYS IVTEGGDKEK LEAFVNFCED AIFEMTHASG 
4381:	LMATDDGGGN VKRDTAYSSY MSEEEEERAA RDPIRRTITA VKEGLKFGVH MLSPANIKHQ 
4441:	IGVMQTKSIP ELIVGFFKII FYIFYYTGYA HFCVVRYIFG ILLNLMRGPA PEQEEEPVVE 
4501:	EETFGRALPP LPLEEPPGTV QAFGLDINKE ENGMYKVVVH ESPANSSMEE GGESSPEDGA 
4561:	AASGELVEGE PHQEPISIVD LLGGEAAKKA AQERQEAQKA QEAAMASIEA EAKKSSSAPQ 
4621:	ETPAVHQIDF SQYTHRAVSF LARNFYNLKY VALVLAFSIN FMLLFYKVTS FTEEADSSAE 
4681:	EELILGSGSG GGADITGSGF GGSGDGGSGD GEMEDEIPEL VHVDEDFFYM EHVLRIAACL 
4741:	HSLVSLAMLI AYYHLKVPLA IFKREKEIAR RLEFEGLFIA EQPEDDDFKS HWDKLVISAK 
4801:	SFPVNYWDKF VKKKVRQKYS ETYDFDSISN LLGMEKSTFA AQESEETGIF KYIMNIDWRY 
4861:	QVWKAGVTFT DNAFLYSLWY FSFSVMGNFN NFFFAAHLLD VAVGFKTLRT ILQSVTHNGK 
4921:	QLVLTVMLLT IIVYIYTVIA FNFFRKFYIQ EEDEEVDKKC HDMLTCFVFH LYKGVRAGGG 
4981:	IGDEIGDPDG DDYEVYRIIF DITFFFFVII ILLAIIQGLI IDAFGELRDQ LESVKDNMES 
5041:	NCFICGMGKD FFDIVPHGFD THVQKEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ 
5101:	RSWDFFPVGD CFRKQYEDEL SGGGGGG