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1.A.3.2.1
Inositol 1,4,5-trisphosphate receptor-2 with 2701 aas and 6 TMSs.  Mediates release of intracellular calcium which is regulated by cAMP both dependently and independently of PKA and plays a critical role in cell cycle regulation and cell proliferation.  High level expression in humans is an indication of cytogenetically normal acute myeloid leukemia (CN-AML) (Shi et al. 2015). .  

Accession Number:P29995
Protein Name:IP3S aka ITPR2
Length:2701
Molecular Weight:307058.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: P29995
eggNOG: roNOG05144
RefSeq: NP_112308.1   
Entrez Gene ID: 81678   
Pfam: PF08709    PF00520    PF02815    PF08454    PF01365   
KEGG: rno:81678   

Gene Ontology

GO:0030424 C:axon
GO:0016021 C:integral to membrane
GO:0043209 C:myelin sheath
GO:0005220 F:inositol 1,4,5-trisphosphate-sensitive calc...
GO:0006816 P:calcium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Structure of a novel InsP3 receptor.”  Suedhof T.C.et.al.   1655411
[2] “Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.”  Yang J.et.al.   12032348

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLTNPP KKFRDCLFKV 
61:	CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSKV 
121:	IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD 
181:	KVVLMPVNAG QPLHASNVEL LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV 
241:	RLFHAEQEKF LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 
301:	SLFRFKHLAT GNYLAAELNP DYRDAQNEGK TVRDGELPTS KKKHQAGEKI MYTLVSVPHG 
361:	NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TSIPIDTEEE RPVMLKIGTC 
421:	QTKEDKEAFA IVCVPLSEVR DLDFANDANK VLATTVKKLE NGSITQNERR FVTKLLEDLI 
481:	FFVADVTNNG QDVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED 
541:	LGDQRYAPYK YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 
601:	NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE LICKFMLSPG 
661:	NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAREGT 
721:	KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR 
781:	LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE 
841:	YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 
901:	SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSWPDAQPSV HPSKQASPGE 
961:	QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF GENDGNGDPS ASGTPETLLP 
1021:	SALVPDIDEI AAQAETMFAG RKEKTPVQLD DEGGRTFLRV LIHLIMHDYA PLLSGALQLL 
1081:	FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD 
1141:	MGEGQAKGGE EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 
1201:	NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP QNQVLLHKHL 
1261:	NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD 
1321:	GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLNMMC SERARGDESG PLAYHITLVE 
1381:	LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE 
1441:	IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 
1501:	SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA IPVDLDSQVN 
1561:	TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM 
1621:	MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE 
1681:	MLEKKDSFME ESSTLRKILL NRYFKGDHSV GVNGPLSGAY AKTAQVGGGF TGQDADKTGI 
1741:	SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ NSFYQQLHEQ 
1801:	KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDLMALGPRM RVRDSSLHLK 
1861:	EGMKGQLTEA SSATSKAYCV YRREMDPDID TMCPGQEAGS AEEKSAEEVT MSPAITIMRP 
1921:	ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINEK 
1981:	NVALVNQTLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILSDINPLG KYRMDLVLQL 
2041:	KNNASKLLLA IMESRHDSEN AERILFNMRP KELVDVMKNA YNQGLECNHG DEEGGDDGVS 
2101:	PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE IVRHDRTMEQ 
2161:	IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF 
2221:	WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PLFSALLWVA VAICTSMLFF 
2281:	FSKPVGIRPF LVSIMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV 
2341:	ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 
2401:	LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNDGV PTMTLTSMLG TCPKENCSPT 
2461:	IPSSNAAGEG GEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY 
2521:	DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQKKEKILKT TCFICGLERD KFDNKTVSFE 
2581:	EHIKSEHNMW HYLYFIVLVK VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD 
2641:	SEQNEIRNLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHENHHMPP 
2701:	H