TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.3.2.16
Inositol triphosphate receptor, IP3R, also called Itr-1, Dec-4 and Ife-1, of 2892 aas and 6 TMSs (Baylis and Vázquez-Manrique 2012).  Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both 1,4,5-InsP3 and 2,4,5-InsP3 with high affinity and does not discriminate between the phosphate at the 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (Dal Santo et al. 1999). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (Walker et al. 2002Gower et al. 2005). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (Thomas-Virnig et al. 2004; ). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde (Walker et al. 2009).

Accession Number:Q9Y0A1
Protein Name:Inositol 1,4,5-trisphosphate receptor itr-1
Length:2892
Molecular Weight:330837.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNPSYGRVRK KVSIISIPEF VPEHYEYENE TTASGGASGG GSTRIEFDFD DFEEQIMRKS 
61:	SMALPSRKLT IANSIDHGNN GNLHIGDIIS LYTESSSNQE QRGFLSTLGL VDDRCIVELK 
121:	DGRPESPPKK FRDCLFKVCP VNRYAAQKHL WTEQKRFQTG DSMFDDDLMN KLKVAADKER 
181:	EENESEFQKT LGNVIQYGSM VQLLHVKSNK YITVQKNSPA KRERNAMKVY LDRAGNEGSW 
241:	FIIEPAYKHY AIGDNVSAGN KISLIPNSVS TTQAGHVKSQ LHLSSFNLLD HQSAAEVNCL 
301:	NEPTEWQVFM FLLFDENQQN SVKSGDVVRL FHADQQTFLT LDTIPKQNPP TDVVFLRMTN 
361:	RPSAADATSS RALWEVQVVQ TNAYRGGTAK WNKAYRFKHL ATDMYLSAEP SQVQVKPAMN 
421:	GRRASLIYSK TNNPMAMYSD GPNGVTNEST DTTQQNIPSV WVLGPTKSEF PEEDANLLFQ 
481:	LDPSTFMKSN KEVPRRSYVR LLHQSSDKWV HATNATEKQN LHYSSKNEKG WVKVICEKNR 
541:	VDKETFALLP VNPDEVRDLD FANDACKALR NFIKLIKIGQ VISKESINST TQLLIDCILF 
601:	VTNSSDHLAD PLKISDFSPS RDRQKLLREQ EVLNQVFLLL KAPFLPRQGT TELGPLLSSP 
661:	SELSDSRNEI FKTMFQLCYC LLKYSQVSYR KNQEFLAEKF GEIQEQIGFD LMAEDTMTAV 
721:	LHNNPKLLEK YVKTPHVERF VELVRNNRQG KFLDYLADLC VCRGEANKKI QELICTSVLS 
781:	SKHRDIFMDT KIIDGEIEVG WAPNFRKLVD IAEGAKSNSD DAEHLDYYRH QLDLLSQMCQ 
841:	EQQYLAIDPP PERRLMNISQ QLPAELVLQC MSDNRLPYDL RGSFTRLMLH LHVVRGSPMS 
901:	AIRHARLWWS IPENVNVSTY ESVSVEAYSD GSRMRIGEGI AHKVLATVET YLMGLRNQSM 
961:	EERQSVNSSK LTYEIVNLAK ALAQFNFYSF NDLLQLTQNL LAIINEGPAT EQVPSHRAMV 
1021:	NAIRNMSKSM MRGGNKENSK DLAKTPSVTA EEAGRTKEGR ALNVKTKLIV AEILQFVMDV 
1081:	RRDYRITMAL SWFKNVFPCD EDGSLMHSAS INERMASELY DAIYRSSGHE LHLDGRDGQL 
1141:	LLAILLQMTM SDYPPLTSIA LKVFFRHFTQ YQELLEDLKQ VQLLVSNNDV ENYRQIDRDL 
1201:	FILKNLTEKS ELWVHGDRHH SIDTKEVDEK ERTTEHDLLD HDLKSPRAFD SGDSMEALMA 
1261:	VLNEHYPSIR NECLQLLNRL LIKDDRNDAA VALQELSDKA PLIAYPLIRQ MLVRLTGMCY 
1321:	RKGDPKPDTM NQQLLKNMRV YEVVLEFISV PHDKKHDHDM MKLITLSHEF LRSFCKTNKE 
1381:	NQSRLYKFIS YEKDAKEGML RVETIEEVGT LVAIFRNNRE LASNVPEELI AHIVGLIEHN 
1441:	SRNPIFLELL QALVCVYDKE IESGQEKVAN EICAASDEVR QLYVDNASFE ELEAMMKDEK 
1501:	ESKGRSSDSR RKLKYHIELV RLLAMCTRGK NGNTELKCAS QIPMDHIVRV VTAKQCLVEV 
1561:	KTVYLQLLLH CYIDTDAEMK DAYKTEYVDH ILNNLLEDIR SLRVEKLTGA ETATLEHYIC 
1621:	HTVTEVLIKF FEAPYSALQQ AKVDVHHHKK TFSEVLLELT YLEKGKLRGS KSSRNWYRVA 
1681:	ECIKRLTKWA EEHNITLPAT LAGPQMSGQT SVRQKWQQAA SSAKWIGIGK RLNRQNTLNP 
1741:	GHRLYGTSNS MTEHTSANVV TCYHMMIGEF KFYLHPLHAA EGSVLVEVLH TPELLFPEGS 
1801:	ALRDQCARGG VVAKLIQHCK TLMQNKQDNL CARVLQTLCK MCDCTKQQLT HQGQQLRQLL 
1861:	LQRYFGHHNN HHPPLDRQQS KIGEVIEAVK EKKEETWSQE RDLYAIQCKL NDAGASDLVT 
1921:	DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV QHSFYMRMKQ KDIHEPFFKA ILTRIQTAQN 
1981:	RLKSDMMSCS DSKPKVSLSA TVSRRSSTVL TPLIDAGDTG FNGALFEVPQ QVRHPSISEM 
2041:	SQLSNDLTHS IPDLAPYQDE EKSTDALPPE VALVEPILRV LQLLCENHNS LLQNFLRKQS 
2101:	DRTNHNLVSE TLSFLDTVCG STKGSLGVFG EIGEHNFSLI TQTLATLTEF CQGPCHENQN 
2161:	TMAMQENGLN IIISLVLNEI KPLADDHMEL ALEIKSQASK LLLAIMESRH DGENANRVLR 
2221:	NMANMSGGPK QLVHAIKQAY EMTNSNHHML KSISRDLFRQ AEDDLKKKSG PQITVNTVTL 
2281:	PEINVDASGI VSIHTEKNIS SSLDDKFNDD DIPSVDPREV GHNIYILAHQ LAIHDGELEI 
2341:	WLDGSDEKKD DLTREALNYY KERTAQIEIV RRDRTLERVV FPINDICSYL TKDTKDYVYN 
2401:	NTERDNQGSK VTEFFDEWET MYHEMIWQRK LQDRKWLSWC AFRLPLWTRL SFHFAFIVNA 
2461:	LVARYYPLPE HSNSSISLGN LYSWFAVFSS FLLAHYLRHD KIYLHKTSLL ILASLCFLLL 
2521:	SSIGVTLTLY IFGILQLVNK IVHVVAFVSN KGLEDRPIAE ILACRNLHYL LVYLFICILG 
2581:	LLVHPMIYCI LLFDIIFTEE TLQNVIASVT RNYQSIVWTG LLALILLYFF SILGFLYFRH 
2641:	DFYLEVDPVE NDSSATISSG IPSETCPSEG CPGLQPSEKD DNDDEKKVKS CETLWMCILQ 
2701:	TGYQGLRNGG GIGDVLRNPA PWEDMFIWRV AYDMTFFVVL IVIVLNLIFG VIIDTFGDLR 
2761:	AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FETHRETEHN IWHYLYYIVM LQIKDETEFT 
2821:	GPESYVAQCV KDRNLDWFPR MQALSLQDSE LDTDQSEVKQ MKDQLLQMMT LMREIISQNE 
2881:	ESRAFMEQFQ PR