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1.A.3.2.2
The Inositol 1,4,5- triphosphate (InsP3)-like receptor (2838aas). Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. May be involved in visual and olfactory transduction as well as myoblast proliferation.   Loss in adult neurons results in obesity in adult flies (Subramanian et al. 2013).

Accession Number:P29993
Protein Name:Inositol 1,4,5-trisphosphate receptor
Length:2838
Molecular Weight:319107.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: inNOG08498
RefSeq: NP_730941.1    NP_730942.1   
Entrez Gene ID: 40664   
Pfam: PF08709    PF00520    PF02815    PF08454    PF01365   
KEGG: dme:Dmel_CG1063   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005220 F:inositol 1,4,5-trisphosphate-sensitive calc...
GO:0007629 P:flight behavior
GO:0007591 P:molting cycle, chitin-based cuticle
GO:0016319 P:mushroom body development
GO:0000280 P:nuclear division
GO:0051209 P:release of sequestered calcium ion into cyt...
GO:0006979 P:response to oxidative stress
GO:0007608 P:sensory perception of smell
GO:0030322 P:stabilization of membrane potential
GO:0055085 P:transmembrane transport
GO:0007601 P:visual perception

References (5)

[1] “Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster.”  Yoshikawa S.et.al.   1322910
[2] “Sequencing and exon mapping of the inositol 1,4,5-trisphosphate receptor cDNA from Drosophila embryos suggests the presence of differentially regulated forms of RNA and protein.”  Sinha M.et.al.   10375644
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[5] “Drosophila homologs of two mammalian intracellular Ca(2+)-release channels: identification and expression patterns of the inositol 1,4,5-triphosphate and the ryanodine receptor genes.”  Hasan G.et.al.   1338312

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGDNIIGSAS FLHLGDIVSL YAEGSVCGFL STLGLVDDRT VVCPEAGDLS CPPKKFRDCL 
61:	IKICPMNRYS AQKQFWKAAK QSASSNTDPN LLKRLHHAAE IEKKQNETEN KKLLGTSIQY 
121:	GRAVVQLLHL KSNKYLTVNK RLPSLLEKNA MRVYLDANGN EGSWFYIKPF YKLRSIGDYV 
181:	VVVGDKVILS PVNADQQNLH VAANYELPDN PGCKEVNVLN SSTSWKISLF MEHKENQEHI 
241:	LKGGDVVRLF HAEQEKFLTM DEYKKQYHVF LRTTGRTSAT AATSSKALWE IEVVQHDSCR 
301:	GGAGDWNSLY RFKHLATGHY LAAEAEIDVS AGAMSATSAS GHDLHLGDCS KDSGLSCSTM 
361:	NSTINDKPKG KQYRLVSVPY SADIASVFVL DATTMARPDS LVPQSSYVRL QHICSNTWVH 
421:	ATSIPIDADD DKPVMSMVCC SPIKEDKEAF ALIPVSPVEV RDLDFANDAC KVLATVTSKL 
481:	DNGSISINER RALISLLQDI VYFIAGMENE QNKTKALEFT IKNPIRDRQK LLREQYILKQ 
541:	LFKILQGPFQ EHTAGDGPFL RLDELSDPKN SPYKNIFRLC YRILRLSQQD YRKNQEYIAK 
601:	HFGLMQKQIG YDILAEDTIT ALLHNNRKLL EKHITAAEIE TFVGLVRKNM HNWDSRFLDY 
661:	LSDLCVSNRK AIAVTQELIC KSVLSDKNKD ILIETQVKAL RTGSGPVRCY KGNSEDVCLA 
721:	TLAEDPGDDE DRSDVQSTST TTTWDSASLN EDDGTPSTGD KYEIHLKWTG QPTSRSMADL 
781:	ASCDGGELEA AILNYYRHQL NLFSNMCLNR QYLALNELSP RLDIDLILKC MSDETMPYEL 
841:	RASFCRLMLH LHVDRDPQEP VTPVKYARLW SEIPSKMSIQ DYDGKNQQPD QNKQACRAKF 
901:	NTTIAFVENY LCNVATKVWL FTDQEQNKLT FEVVKLARDL IYFGFYSFSD LLRLTKTLLS 
961:	ILDCVSDTSS GEFASTDIDS VEEETNAEAE GGVLRSIGDI NTVMTSLALG SVGQAIAAPT 
1021:	ISLQQRKSVS QLMKEYPLVM DTKLKIIEIL QFILDVRLDY RISCLLSIFK REFDESEVAA 
1081:	SAASNEASQQ QSQQQEPQTP GSSNETDPLD SAESVAAGAA AAAATTARQK NIDLESIGVQ 
1141:	AEGIFDCERS DAANLDLDGQ GGRTFLRVLL HLIMHDYAPL VSGALHLLFR HFSQRQEVLQ 
1201:	AFRQVQLLVS DSDVESYKQI KSDLDILRQS VEKSELWVYK AKATDELGAT DAGGDAVSLE 
1261:	YNAALSQEQR NEYRKVKEIL IRMNKFCVTA SGPGSVVKPR KHEQRLLRNV GVHTVVLDLL 
1321:	QNPYDEKDDE LMKELMCLAH EFLQNFCLGN QQNQVLLHNH LDLFLNPGIL EAKTVCAIFK 
1381:	DNLALCNEVT DKVVQHFVHC IEIHGRHVAY LQFLQTVVAA ENQFIRRCQD MVMQELINSG 
1441:	EDVLVFYNDK GSFNHFVQMM QQQMLGMEKL SDDSPLKYHV ELVKLLACCT MGKNVYTEIK 
1501:	CNNLLSLDDI VTIICHPLCM PEVKEAYVDF LNHCYIDTEV EMKEIYASGH MWSLFEKSFL 
1561:	VDINQLITNP AAASNKTLQA YVLNGVTNLL GSFFASPFSD QSAIVQSRQL IFVQLLQAAH 
1621:	RITQCRWLSL GDRFNVENCI RTLTESAKMR SIALPPELEQ QVATMSSKTA MLTRQTTKWL 
1681:	LASKQPKYEA QQAASLMRWD RSIIEGLQDI VSLLEDQLKP VVEAELSLLV DILYRSELLF 
1741:	PAGTEARKRC ESGGFIRKLI KHTEKLLEEK EERMCVKVLR TLREMMAIDV NYGEKGDALR 
1801:	QTLLLRYFQT KSTPRLPEDE VPLLAAPLMD PAKQNHLVTH GPGAKYLQRA GKTLHEMQNH 
1861:	LDREGASDLV VELVIKSVHS PNIFVEAVEL GIALLEGGNP IIQKGMFQKF LSDDLNQAFF 
1921:	KVFFEKMKDA QQEIKSTVTV NTTDIAAKAH EHKQDTNLEL DKIARKHGLK SNGVVITEEL 
1981:	KRELHNAGLA TARAYGNARN IHSGEESSAI SVNSPLEDIL AEKLEKHKDS RDQRNQLSNK 
2041:	VLVMQPILRF LQLLCENHNP DMQNLLRNQN NKTNNNLVSE TLMFLDCICG STTGGLGLLG 
2101:	LYINEHNLAL INQTLEALTE YCQGPCHENQ NCIATHESNG LDIITALILN NINPLGENRM 
2161:	DLVLELKNNA SKLLLAIMES RGDSENAERI LYNMNPKQLV EVACKAYHQE ELIDEQDDGD 
2221:	EPDAGSDDDD ATVSPREVGH NIYILCHQLA QHNKELAGLL KASEDPQSAS FDAKTSQALM 
2281:	YYATHTAQIE IVRNDRTLEQ IVFPIPEICE YLTTDTKIKI LNTAERDDQG SKLADFFDKA 
2341:	EEMFNEMKWQ KKLRSQPLLF WISSYMSLWS NILFNCVVVI NMIVAFFYPF DNTVPELSSH 
2401:	ISLLFWIITI FSLVIVLALP RESGIRTFIG SVILRFIFLL GPESTLCLLG VVTVTLKSVH 
2461:	IVSIMGNKGT LEKQLIKIIT DFQLLYHCIY IAFCFCGLIF HPFFYSLLLF DVVYREETLV 
2521:	NVIRSVTRNG RSIVLTAVLA LILVYLFSII GYMFFKDDFL VSVDFEEQDN APPPSVPLTL 
2581:	SVPVSGDSCS APDDLGNCQA AKEVAPPSAG GGEVKERSCD SLVMCIVTTL NQGLRNGGGI 
2641:	GDILRAPSSK EGLFVARVIY DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQQKEAILKT 
2701:	TCFICSLNRS AFDNKTVSFE EHIKSEHNMW HYLYFIVLVK VKDPTEFTGP ESYVYAMVKA 
2761:	GILEWFPRLR AMSLAAVDAD GEQIELRSMQ AQLLDTQLLI KNLSTQLHEL KDHMTEQRKQ 
2821:	KQRLGLLNTT ANSLLPFQ