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1.A.3.2.5
Inositol 1,4,5-triphosphate receptor type 1 splice variant, IP(3)R1 (Subedi et al., 2012).  The human orthologue, IP3R3, is regulated at the ER-mitochondrion interface by BCL-XL (TC# 1.A.21.1.6) (Williams et al. 2016).

Accession Number:Q63269
Protein Name:Inositol 1,4,5-trisphosphate receptor type 3
Length:2670
Molecular Weight:304286.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q63269
eggNOG: NOG280601
Entrez Gene ID: 25679   
Pfam: PF08709    PF00520    PF02815    PF08454    PF01365   
KEGG: rno:25679   

Gene Ontology

GO:0045177 C:apical part of cell
GO:0005903 C:brush border
GO:0005789 C:endoplasmic reticulum membrane
GO:0043209 C:myelin sheath
GO:0043025 C:neuronal cell body
GO:0005640 C:nuclear outer membrane
GO:0015085 F:calcium ion transmembrane transporter activity
GO:0043533 F:inositol 1,3,4,5 tetrakisphosphate binding
GO:0005220 F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0000822 F:inositol hexakisphosphate binding
GO:0005218 F:intracellular ligand-gated calcium channel activity
GO:0060402 P:calcium ion transport into cytosol
GO:0007186 P:G-protein coupled receptor signaling pathway
GO:0051291 P:protein heterooligomerization
GO:0051260 P:protein homooligomerization

References (3)

[1] “Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.”  Blondel O.et.al.   8388391
[2] “Regulating ankyrin dynamics: roles of sigma-1 receptors.”  Hayashi T.et.al.   11149946
[3] “Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.”  Yang J.et.al.   12032348

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC 
61:	PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS 
121:	VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG 
181:	DKVILNPVNA GQPLHASNYE LSDNVGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV 
241:	VRLFHAEQEK FLTCDEYRGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 
301:	NGLYRFKHLA TGNYLAAEEN PSYKGDVSDP KAAGPGAQSR TGRRNAGEKI KYRLVAVPHG 
361:	NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNAPIDVEEE RPIRLMLGTC 
421:	PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV 
481:	FFVSDVPNNG QNVLDIMVTK PNRERQKLMR DENILKQIFG ILKAPFRDKG GEGPLVRLEE 
541:	LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 
601:	NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NRIAIPVTQE LICKCVLDPK 
661:	NSDILIQTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDRN NEHHEKSVRQ LAQEARAGNA 
721:	HDENVLSYYR YQLKLFARMC LDRQYLAIDE ISKQLGVELL FLCMADEMLP FDLRASFCHL 
781:	MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY 
841:	LNNVVGEAVP FANDEKNILT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCIQAPAA 
901:	VLQAYEEPGG KNVRRSIQGV GHMMSTMVLS RKQSVFGASS LPTGVGVPEQ LDRSKFEDNE 
961:	HTVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTAPAFDSST 
1021:	ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE GGRMFLRVLL HLTMHDYPPL VSGALQLLFK 
1081:	HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSVKGEEGE 
1141:	AGASKDKKER PSDEEGFLQP HGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 
1201:	DAHKVMLDLL QIPYDKNDNK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL QLFLTPGLLE 
1261:	AETMQHIFLN NYQLCSEISE PVLQHFVHCW PTHGRHVQYL DFLHTVIKAE GKYVKKCQDM 
1321:	IMTELTNAGD DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN 
1381:	VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL 
1441:	FENFTLDMAL VCNKREKRLS DPTLEKYVLT VVLDTISAFF SSPFSENSTS LQTHQTIVVQ 
1501:	LLQSTTRLLE CPWLQQQHKG SVEACVRTLA MVAKSRAILL PMDLDAHMSA LLSSGGSCSA 
1561:	AAQRSAANYK TATRTFPRVI PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDM 
1621:	LHWPELLFLE GSEAYQRCES GGFLSKLIRH TKGLMESEEK LCVKVLRTLQ QMLQKKSKYG 
1681:	DRGNQLRKML LQNYLQNRKS GPRGELTDPT GSGVDQDWSA IAATQCRLDK EGATKLVCDL 
1741:	ITSTKNEKIF QESIGLAIRL LDGGNTEIQK SFYNLMTSDK KSERFFKVLH DRMKRAQQET 
1801:	KSTVAVNMSD LGSQPREDRE PADPTTKGRV SSFSMPSSSR YSLGPGLHRG HDVSERAQNN 
1861:	EMGTSVLIMR PILRFLQLLC ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DIMCGSTTGG 
1921:	LGLLGLYINE DNVGLVIQTL ETLTEYCQGP CHENQTCIVT HESNGIDIIT ALILNDISPL 
1981:	CKYRMDLVLQ LKDNASKLLL ALMESRHDSE NAERILISLR PQELVDVIKK AYLQEEEREN 
2041:	SEVSPREVGH NIYILALQLS RHNKQLQHLL KPVKRIQEEE AEGISSMLSL NNKQLSQMLK 
2101:	SSAPAQEEEE DPLAYYENHT SQIEIVRQDR SMEQIVFPVP AICQFLTEET KHRLFTTTEQ 
2161:	DEQGSKVSDF FDQSSFLHNE MEWQRRLRSM PLIYWFSRRM TLWGSISFNL AVFINIIIAF 
2221:	FYPYVEGAST GVLGSPLISL LFWILICFSI AALFTKHYSV RPLIVALVLR SIYYLGIGPT 
2281:	LNILGALNLT NKIVFVVSFV GNRGTFIRGY KAMVMDMEFL YHVGYILTSV LGLFAHELFY 
2341:	SILLFDLIYR EETLFNVIKS VTRNGRSILL TALLALILVY LFSIVGFLFL KDDFILEVDR 
2401:	LPGNHSRAST LGMPHGAATF MGTCSGDKMD CVSEVSVPEI LEEDEELDST ERACDTLLMC 
2461:	IVTVMNHGLR NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA 
2521:	DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKL EHNMWNYLYF IVLVRVKNKT 
2581:	DYTGPESYVA QMIKNKNLDW FPRMRAMSLV SGEGEGEQNE IRILQEKLGS TMKLVSHLTA 
2641:	QLNELKEQMT EQRKRRQRLG FVDVQNCMSR