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1.A.3.2.9
CRCI-1a; IP3R.  Functions similarly to TC# 1.A.3.2.7 (Docampo et al. 2013).  Cortical Ca2+ stores (alveolar sacs) are activated during stimulated trichocyst exocytosis, mediating store-operated Ca2+ entry (SOCE). Ca2+ release channels (CRCs) localise to alveoli and are Ryanodine receptor-like proteins (RyR-LPs) as well as inositol 1,4,5-trisphosphate receptors (IP3Rs), members of the CRC family with 6 subfamilies (Plattner 2014).

Accession Number:G7ZU97
Protein Name:Calcium-release channel I-1a
Length:2972
Molecular Weight:348963.00
Species:Paramecium tetraurelia [5888]
Number of TMSs:6
Substrate Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNQEDLNYLT YGSVISISHV QDDHSFITAD GFVKRAVCLQ NFHHIDVVDV KQLGKMKSRP 
61:	YYHTLFQIFP KFTNTTKQEI LKELIGEEQE EEVQPAVQNI LESISKHQKV DEKTILSKEQ 
121:	VQMFSQKLLQ EFKYNLDTFE KSKAHKVSYK SHIQLLHLAS SKFLACHQKE ARVESSNYKI 
181:	TLDELPSDSS LFKILPAYKY QKEGEQVIYA SDIVYIVRAT SFMNKLTFLH ASQEMGNYGK 
241:	SRKQKKSDED LLQYKMEKDI IKREVNAALD EENQTQWRIS VYSDYVPETS GYLKCGDVIW 
301:	LHHSETNTTI AATRKGKPVD QKNFQSFNLV DWLKVENVEL NVLSGSTKES YDEYTGDTHS 
361:	MWIIESEIYK EGGIVVFDKK YRFKHFTSGL YLSGIQDKFT LDKQRVPTTL FYFSQLKNSQ 
421:	VREKSVMRGS YVYICHDKPI PSGTINNQND ENSFWVDIQY GKYQRYIPIL HQEQHKTDQS 
481:	VFKLYASSSN DVWEISFVLS CAKTLTNYLD DLQKLKWEND AQDKEVLKDH LLKIQTTKQC 
541:	IEDINDFCNN RLYNSTPEQK YGTINPFRQK LLKEQYYIDL LVKILVQQLK PEDLVIWSRR 
601:	FMIIQMQDIQ QQQEKMSNTE QTNKKQGLKD HEILAYIAFK ITLNQTIYTL LTSICKQNPE 
661:	NELYTFDLIG HFLEHCRYIP EAIKCMISII GNNPELLQQL SLNMKLDYIP KEQDFFEPEE 
721:	EKMQLHHNKI QNNFLIFFLN LLETDEQAHK ADFLTFLREM CIYNSQGINS NQEAIYKLLK 
781:	KHNHKKIQLI KDREDPDKIS LKDGKLVIPF KLQNDPKEMY FINEQLQFYA DVSYGRNYLW 
841:	KQELEQYFSK DFLFQNIWQE DGNRTYAVLQ AALCKIAMSL YIDHDPLNKV QLPKYCNLFK 
901:	SIDKANEAQH MGLYTSLIED LFKYLQDNKQ QIVLALDTKD SGDNNKDYDM LEANDEKSLL 
961:	INELLYNSCQ MMLLVLELDV FLLLDKEPNQ YYKQIIDIVI HYFFYDFTQL PLMKSVYKVQ 
1021:	KSEITQRKER KEVNPLGIGL NLGANLISMA NPMNIGLNLN LFGSDEEQKS ESDDDEQIDE 
1081:	GIVDDVQMYT NPLMRGFIKL ENELQSTLLT REETGSSQLE IKIKLTLCDV MDRFLDMRQN 
1141:	YLMLNCLSFF KKQIIEKMQE GIQQLKFSKD DASQEQEETK ILIFVQRKTE SNLLGLMPNI 
1201:	AKTGLKEVDE KEEKQDAFGI GALNFLNKLA ETKPESEEFK VFTQNEMLIY DLDQYFSLNL 
1261:	PQEDISKINN PIGVVLPYLF TNFSQIHEEE LEKRCLAIIM RLFNQREELC NNLLKLQLVS 
1321:	DPIKSRLYEF LSENLQRLNQ LVDRSEVWLA EYIKSQKQDD LEETLEIIDN FRQGFFKDTQ 
1381:	ISSKIISGTQ EIDAEKQNLM NALKIHLPIL NLIRDQMSAL DFHLENIKNI QRKQRLAQLF 
1441:	IYAFQFLTYF CRNNHENQIV LSQYISYFEN MHLEVGQIPL ICEIYKDNQK LLTSINRNDR 
1501:	VFHKFVELIY QSGRKAQFLD FFLTIIKQGN KYIFDNQLLV LNTFLEKEEL LFTEKNEFVF 
1561:	EGDIQLHQSD FLTDLASNPP MNQPFLYHAK LLDLLLQCTQ IQVLEGDQKD NFTINVAKLK 
1621:	KKFSAQYMIQ LLCKPDSLCS RNPSLQEQGF GLIKKQLWIF FMNVHITSEK SQNFLKEIKN 
1681:	DLLNMIDFEI KRLEHIQFDH QQLRYFDFLI EAVIPLFTTY LIRKNISVHQ DEDEDGHDQE 
1741:	QKDIAAFQAF AKTLSSKILH LGKYVNRKKH VSVLIAFYSY FPLTIMGKVC QSVSGQSKLM 
1801:	EDLGEFNGFR DVLSNIQAGA NDNYQSDLNE QVIHLQSGIQ QSHGDHHTPK TIFQSNNVKS 
1861:	KIGIMSALSS NKKQKEEPLI EFESAEIEKI SGSWEEFVNQ LCLSDKSKNY VQDELQKLSE 
1921:	AIVKFEQYFG NPSDKNDKNE KILKVEYVIL LKKFINFLSY AINSSQNNKT IITLLGVLRK 
1981:	VIEGKPKEEQ KEKVEVEGEN NEMEDVQNLF NKLGATRMVL TVLSESIILD GEMLRNFLLF 
2041:	INTLLSGGNN KVQKTIFEFM KTYPKSEVIF SRLNNVIQAQ IKQITNKEKD KKTEEQQLGN 
2101:	LPSQQQEDNV QELKQQQDLE LLLTQVLKFL QNCCEGHYLD LQNYIRQQTN SRNSFNMINQ 
2161:	VAELLLTYYY KDRAQYENMV LCLDTLNELV QGPCPENQIA VADSKFFEIA SDLFGQKKEK 
2221:	DSTGKTQIMI SNIKTSKTQN NKMMTSKTGR YQKQQKGSDL KIWQIERMQT KCLILILSLI 
2281:	EMREISDSNP IIKRIMRHLT PPLLEKHMVS CFHKYEKQCK EGYQIEVLDR IKEDPESAKQ 
2341:	EDKVKEEQYY ELILQKGFYI YFLMSYYMES EKNVENSFVQ MYRANTRKKL KQDKGTLEDL 
2401:	LFGDNIIGQL VSFVMSFANS WIDLMNQIKK EAQKQMATQA QTSEQQEKQD RERRAEKEKM 
2461:	KRRAFDFFYK NSASIEVVRN NEIEIVYFLL LPYTHNLPKE QKVEFHENVD RSSTKSKVQF 
2521:	LVQESERLTE ICEHEEQLRR IFQRQKFLAL FANYVKLWKD LAFLFTLLLN LFIIGSFAQN 
2581:	ESGNRITDFR LFRDEQYSPQ QTRNIFLICG TIMACCSIFV VSFFLFKNAP LIIKKAWKTK 
2641:	LPFEDKFTYW PIQLIYKIFK LLAVLFYILK EIEVVYYLAY GALAVIGTVL HPFFFSFHLT 
2701:	EILIRYPTLK NVIRSVWEPK QQLGLTLVLF VILVYVYGLI AYTFFFEDYK GKCQSTLFCF 
2761:	LFTFDWTFKA NGGVGGYLSD LEDEDVVEKY RVSRFVFDNT SNIFLVIIMV NIVAGIIIDT 
2821:	FGSLREEESD KVRDIEDKCF ICGNLKTTFD RLTDTASMGG GFDHHIKVNH YMWNYVFFMA 
2881:	YLKYKDPTDY TGIEQFVWEK IQKKDLTWFP FNKARELQNI KQDEEEESKK IERISKDIVN 
2941:	IVDTMRQASQ MLNSIKNRKK LRNAAKQPAD ML