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1.A.31.1.2
Annexin VI

Accession Number:P08133
Protein Name:Annexin A6 aka Annexin VI aka Lipocortin VI aka P68 aka P70 aka Protein III aka Chromobindin 20 aka 67 kDa calelectrin aka Calphobindin-II aka CPB-II
Length:673
Molecular Weight:75873.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate ions

Cross database links:

Genevestigator: P08133
eggNOG: prNOG18224
HEGENOM: HBG444222
RefSeq: NP_001146.2    NP_004024.2   
Entrez Gene ID: 309   
Pfam: PF00191   
OMIM: 114070  gene
KEGG: hsa:309   

Gene Ontology

GO:0042470 C:melanosome
GO:0005509 F:calcium ion binding
GO:0005544 F:calcium-dependent phospholipid binding
GO:0005515 F:protein binding

References (12)

[1] “Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.”  Crompton M.R.et.al.   3258820
[2] “Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.”  Suedhof T.C.et.al.   2963335
[3] “Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor.”  Iwasaki A.et.al.   2528541
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Structure and properties of calphobindin II, an anticoagulant protein from human placenta.”  Yoshizaki H.et.al.   2139657
[7] “Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.”  Aboulaich N.et.al.   15242332
[8] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[9] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[10] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[11] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[12] “The structure of recombinant human annexin VI in crystals and membrane-bound.”  Benz J.et.al.   8709144
Structure:
1M9I     

External Searches:

  • Search: DB with
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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FASTA formatted sequence
1:	MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ 
61:	SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA 
121:	SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD 
181:	VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 
241:	LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 
301:	LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA 
361:	NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE 
421:	ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED 
481:	YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK 
541:	TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 
601:	PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 
661:	FLKALLALCG GED