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1.A.35.1.1
Divalent cation (Mg2+, Co2+ and Ni2+) transport system, CorA.  Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction, thus defining the gating mechanism (Dalmas et al. 2014).

Accession Number:P0ABI4
Protein Name:Magnesium transport protein CorA aka B3816
Length:316
Molecular Weight:36590.00
Species:Escherichia coli [83333]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Co2+, Mg2+, Ni2+

Cross database links:

Genevestigator: P0ABI4
EchoBASE: EB1431
EcoGene: EG11463
eggNOG: COG0598
HEGENOM: HBG350378
RefSeq: AP_003984.1    NP_418260.1   
Entrez Gene ID: 948351   
Pfam: PF01544   
BioCyc: EcoCyc:CORA-MONOMER    ECOL168927:B3816-MONOMER   
KEGG: ecj:JW3789    eco:b3816   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015087 F:cobalt ion transmembrane transporter activity
GO:0015095 F:magnesium ion transmembrane transporter act...
GO:0006824 P:cobalt ion transport
GO:0015693 P:magnesium ion transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein.”  Smith R.L.et.al.   8314774
[2] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[3] “Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes.”  Plunkett G. IIIet.al.   8346018
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology.”  Park M.H.et.al.   780341
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSAFQLENN RLTRLEVEES QPLVNAVWID LVEPDDDERL RVQSELGQSL ATRPELEDIE 
61:	ASARFFEDDD GLHIHSFFFF EDAEDHAGNS TVAFTIRDGR LFTLRERELP AFRLYRMRAR 
121:	SQSMVDGNAY ELLLDLFETK IEQLADEIEN IYSDLEQLSR VIMEGHQGDE YDEALSTLAE 
181:	LEDIGWKVRL CLMDTQRALN FLVRKARLPG GQLEQAREIL RDIESLLPHN ESLFQKVNFL 
241:	MQAAMGFINI EQNRIIKIFS VVSVVFLPPT LVASSYGMNF EFMPELKWSF GYPGAIIFMI 
301:	LAGLAPYLYF KRKNWL