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1.A.35.1.2
Divalent cation (Mg2+, Co2+ and Ni2+) transport system, CorA

Accession Number:P0A2R8
Protein Name:Magnesium transport protein CorA aka STM3952
Length:316
Molecular Weight:36593.00
Species:Salmonella typhimurium [90371]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Ni2+, Co2+, Mg2+

Cross database links:

HEGENOM: HBG350378
RefSeq: NP_462837.1   
Entrez Gene ID: 1255478   
Pfam: PF01544   
BioCyc: STYP99287:STM3952-MONOMER   
KEGG: stm:STM3952   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015087 F:cobalt ion transmembrane transporter activity
GO:0015095 F:magnesium ion transmembrane transporter act...
GO:0006824 P:cobalt ion transport
GO:0015693 P:magnesium ion transport
GO:0055085 P:transmembrane transport

References (10)

[1] “Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein.”  Smith R.L.et.al.   8314774
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Magnesium transport in Salmonella typhimurium: characterization of magnesium influx and cloning of a transport gene.”  Hmiel S.P.et.al.   3536881
[4] “Magnesium transport in Salmonella typhimurium: genetic characterization and cloning of three magnesium transport loci.”  Hmiel S.P.et.al.   2548998
[5] “Magnesium transport in Salmonella typhimurium: (28)Mg2+ transport by the CorA, MgtA, and MgtB systems.”  Snavely M.D.et.al.   2670893
[6] “The CorA Mg2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg2+ pore.”  Smith R.L.et.al.   9786860
[7] “The CorA Mg(2+) transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the second membrane domain.”  Szegedy M.A.et.al.   10601252
[8] “Cation hexaammines are selective and potent inhibitors of the CorA magnesium transport system.”  Kucharski L.M.et.al.   10748031
[9] “The CorA Mg2+ transporter is a homotetramer.”  Warren M.A.et.al.   15231793
[10] “The CorA Mg2+ transporter does not transport Fe2+.”  Papp K.M.et.al.   15516579

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLSAFQLEKN RLTRLEVEES QSLIDAVWVD LVEPDDDERL RVQSELGQSL ATRPELEDIE 
61:	ASARFFEDED GLHIHSFFFF EDAEDHAGNS TVAFTIRDGR LFTLRERELP AFRLYRMRAR 
121:	SQAMVDGNAY ELLLDLFETK IEQLADEIEN IYSDLEKLSR VIMEGHQGDE YDEALSTLAE 
181:	LEDIGWKVRL CLMDTQRALN FLVRKARLPG GQLEQAREIL RDIESLLPHN ESLFQKVNFL 
241:	MQAAMGFINI EQNRIIKIFS VVSVVFLPPT LVASSYGMNF EFMPELKWSF GYPGAIIFMI 
301:	LAGLAPYLYF KRKNWL