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1.A.35.2.2
Putative manganese resistance, Mg2+ transport protein MnR2p

Accession Number:P35724
Protein Name:MNR2 aka YKL064W
Length:969
Molecular Weight:109737.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

Genevestigator: P35724
eggNOG: fuNOG05794
HEGENOM: HBG397215
DIP: DIP-8080N
RefSeq: NP_012859.1   
Entrez Gene ID: 853801   
Pfam: PF01544   
KEGG: sce:YKL064W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0005515 F:protein binding
GO:0010961 P:cellular magnesium ion homeostasis
GO:0030001 P:metal ion transport
GO:0055085 P:transmembrane transport

References (8)

[1] “Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins.”  Rasmussen S.W.et.al.   8091862
[2] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[6] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358
[7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[8] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSTDNSQKDE GVPLLSPYSS SPQLRKKKRN QKRRKDKFVG HLKSDSRRPT QLLHDNLQHN 
61:	HGQITDFDQI DSWGMLHESD STSNDIIKSE DPSLKGAFID HRPSMSQPRE GPQSVSSTVQ 
121:	PQPIMKFSTP SYKKPAGLRP SDQNRSLVSD LSPSELESWL KRRKSVHKSF VDENSPTDRR 
181:	QSNANNDVVI DVDALMNHVN NNASTGVNDN SKRRKKKRGS DDSSNKNSKS TSSDSNDEED 
241:	EYNSRPSSSL SSNNSSLDDV CLVLDDEGSE VPKAWPDCTV LEEFSKEETE RLRSQAIQDA 
301:	EAFHFQYDED EEDGTSNEDG ILFSKPIVTN IDVPELGNRR VNETENLKNG RLRPKRIAPW 
361:	HLIQRPMVLG SNSTKDSKSR IQSGLQDNLL VGRNIQYPPH IISNNPEHFR FTYFRVDLDS 
421:	TVHSPTISGL LQPGQKFQDL FVASIYSQDN SAGHIKTHPN SPTPGIKAET VSQLQGLTAK 
481:	NPSTLSSMSV ANIEDVPPFW LDVSNPTEEE MKILSKAFGI HPLTTEDIFL GEVREKVELF 
541:	RDYYLICFRS FDIVAEKHVR RRRKEKQESA TLDHESISRR KSQAYGATMS NESNANNNNS 
601:	TSNASRSKWL PSILRARRRS SANRTTNTSS SSYKRRVKSE KKKMEENEKF KRKSGDRHKP 
661:	REGELEPLNV YIIVFRTGVL TFHFAPTPHP INVRRRARLL KDYLNVTSDW IAYALIDDIT 
721:	DAFAPMIELI EDEVYEIEDA ILKMHQSDDS SDSDSSDSDS DSGASDEDAF PFDVYSKKTS 
781:	YSSAKSSVSS RSMSTSEASF NANLIGWKRK GDMLRRIGEC RKRVMSILRL LGSKADVIKG 
841:	FAKRYNEQWE ASPQSEIAMY LGDIQDHIVT MVSSLNHYEK LLSRSHSNYL AQINIDMTKV 
901:	NNDMNDVLGK ITILGTIVLP MNVITGLWGM NVIVPGQYRD SLTWFIGIVL FMCMLACSAY 
961:	MYTKRRFGF