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1.A.35.4.1
Zn2+/Cd2+ efflux system, ZntB. Mg2+ is not transported. Wan et al. 2011 reported crystal structures in dimeric and physiologically relevant homopentameric forms at 2.3 Å and 3.1 Å resolutions, respectively. The funnel-like structure is similar to that of the homologous Thermotoga maritima CorA Mg2+ channel and a Vibrio parahaemolyticus ZntB (VpZntB). However, the central α7 helix forming the inner wall of the StZntB funnel is oriented perpendicular to the membrane instead of the marked angle seen in CorA or VpZntB. Consequently, the StZntB funnel pore is cylindrical, not tapered, which may represent an "open" form of the ZntB soluble domain. There are three Zn2+ binding sites in the full-length ZntB, two of which could be involved in Zn2+ transport.

Accession Number:Q9EYX5
Protein Name:ZntB aka STM1656
Length:327
Molecular Weight:36759.00
Species:Salmonella typhimurium [90371]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cd2+, Zn2+

Cross database links:

HEGENOM: HBG321170
RefSeq: NP_460615.1   
Entrez Gene ID: 1253174   
Pfam: PF01544   
BioCyc: STYP99287:STM1656-MONOMER   
KEGG: stm:STM1656   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (3)

[1] “ZntB is a novel Zn(2+) transporter in Salmonella enterica serovar Typhimurium.”  Worlock A.J.et.al.   12142406
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Membrane topology of the ZntB efflux system of Salmonella enterica serovar Typhimurium.”  Caldwell A.M.et.al.   12486076
Structure:
3NVO   3NWI     

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAIKGSDVN VPDAVFAWLL DGRGGVKPLE DNDVIDSQHP CWLHLNYTHP DSARWLASTP 
61:	LLPNNVRDAL AGESSRPRVS RMGEGTLITL RCINGSTDER PDQLVAMRLY MDERFIVSTR 
121:	QRKVLALDDV VSDLQEGTGP VDCGGWLVDV CDALTDHASE FIEELHDKII DLEDNLLDQQ 
181:	IPPRGFLALL RKQLIVMRRY MAPQRDVYAR LASERLPWMS DDHRRRMQDI ADRLGRGLDE 
241:	IDACIARTGI MADEIAQVMQ ESLARRTYTM SLMAMVFLPS TFLTGLFGVN LGGIPGGGWR 
301:	FGFSLFCILL VVLIGGVTLW LHRSKWL