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1.A.35.5.2
High affinity root Mg2+ transporter, Mrs2/MGT1.  Plants have up to 10 Mrs2 homologues, and they can form homo as well as heterooligomeric channels (Schmitz et al. 2013). Expression in an E. coli triple mutant, corA mgtA yhiD, which required high (>10 mM) Mg2+ for growth, allowed growth on >1 mM Mg2+ and resulted in Al3+ sensitivity (Ishijima et al. 2015).

Accession Number:Q9SAH0
Protein Name:F23A5.26 protein
Length:443
Molecular Weight:50463.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+, Al3+

Cross database links:

Genevestigator: Q9SAH0
RefSeq: NP_565247.1   
Entrez Gene ID: 844430   
Pfam: PF01544   
KEGG: ath:AT1G80900   

Gene Ontology

GO:0016020 C:membrane
GO:0015095 F:magnesium ion transmembrane transporter act...
GO:0030001 P:metal ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “A novel family of magnesium transport genes in Arabidopsis.”  Li L.et.al.   11752386
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Overexpression of an Arabidopsis magnesium transport gene, AtMGT1, in Nicotiana benthamiana confers Al tolerance.”  Deng W.et.al.   17101715
[4] “A root-expressed magnesium transporter of the MRS2/MGT gene family in Arabidopsis thaliana allows for growth in low-Mg2+ environments.”  Gebert M.et.al.   19966073

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSELKERLLP PRPASAINLR GDAGSRPSPS GRQPLLGVDV LGLKKRGQGL KSWIRVDTSA 
61:	NSQVIEVDKF TMMRRCDLPA RDLRLLDPLF VYPSTILGRE KAIVVNLEQI RCIITADEVL 
121:	LLNSLDNYVL RYVVELQQRL KASSVTEVWN QDSLELSRRR SRSLDNVLQN SSPDYLPFEF 
181:	RALEVALEAA CTFLDSQASE LEIEAYPLLD ELTSKISTLN LERARRLKSR LVALTRRVQK 
241:	VRDEIEQLMD DDGDMAEMYL TEKKKRMEGS LYGDQSLPVY RTNDCFSLSA PVSPVSSPPE 
301:	SRRLEKSLSI VRSRHDSARS SEDATENIEE LEMLLEAYFV VIDSTLNKLT SLKEYIDDTE 
361:	DFINIQLDNV RNQLIQFELL LTTATFVVAI FGVVAGIFGM NFEIDFFEKP GAFKWVLAIT 
421:	GVCGLVVFLA FLWYYKRRRL MPL