1.A.37 The CD20 Ca2+ Channel (CD20) Family
The B-lymphocyte differentiation antigen, CD20 (also called B1, Leu-16 and BP35), is a protein of 297 aas with 4 TMSs (Tedder et al., 1989). Both the N- and C-termini are in the cytoplasm. The protein is phosphorylated by one or more ser/thr protein kinases that may regulate its role in B-cell activation and proliferation. Transfection of CD20 into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes (Bubien et al., 1993). The CD20 Ca2+-permeable cation channel expressed in Balb/c3T3 cells is activated by insulin-like growth factor and the α-subunits of G-proteins (Kanzaki et al., 1997a,b). It is a store-operated calcium entry modulator in skeletal muscle (Parolini et al. 2012). Homologues include the high affinity IgE receptor, the testes development regulated protein NYD-SP21 and the Chandra protein. Homologues with BLAST scores above threshold are found only in mammals.