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1.A.37.1.1
The CD20 cation channel (B-lymphocyte CD20 antigen)

Accession Number:P11836
Protein Name:CD20 aka MS4A1
Length:297
Molecular Weight:33077.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: P11836
eggNOG: prNOG05555
HEGENOM: HBG282650
RefSeq: NP_068769.2    NP_690605.1   
Entrez Gene ID: 931   
Drugbank: Drugbank Link   
OMIM: 112210  gene
KEGG: hsa:931   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0042113 P:B cell activation
GO:0006955 P:immune response

References (8)

[1] “Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.”  Stamenkovic I.et.al.   3260267
[2] “Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.”  Tedder T.F.et.al.   2448768
[3] “Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains.”  Einfeld D.A.et.al.   2456210
[4] “Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).”  Tedder T.F.et.al.   2466899
[5] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.”  Teeling J.L.et.al.   16785532
[8] “Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.”  Carrascal M.et.al.   19367720
Structure:
1S8B   2OSL   3BKY   3PP4     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTPRNSVNG TFPAEPMKGP IAMQSGPKPL FRRMSSLVGP TQSFFMRESK TLGAVQIMNG 
61:	LFHIALGGLL MIPAGIYAPI CVTVWYPLWG GIMYIISGSL LAATEKNSRK CLVKGKMIMN 
121:	SLSLFAAISG MILSIMDILN IKISHFLKME SLNFIRAHTP YINIYNCEPA NPSEKNSPST 
181:	QYCYSIQSLF LGILSVMLIF AFFQELVIAG IVENEWKRTC SRPKSNIVLL SAEEKKEQTI 
241:	EIKEEVVGLT ETSSQPKNEE DIEIIPIQEE EEEETETNFP EPPQDQESSP IENDSSP