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1.A.4.1.5
transient receptor potential canonical-6, TRPC6,  a non-selective cation channel that is directly activated by diacylglycerol (DAG (Szabó et al. 2015). Mutation causes a particularly aggressive form of familial focal segmental glomerulosclerosis (Winn et al., 2005; Mukerji et al., 2007). 

Accession Number:Q9Y210
Protein Name:Short transient receptor potential channel 6 aka TRPC6
Length:931
Molecular Weight:106326.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: Q9Y210
eggNOG: prNOG06953
HEGENOM: HBG355804
RefSeq: NP_004612.2   
Entrez Gene ID: 7225   
Pfam: PF00520    PF08344   
OMIM: 603652  gene
603965  phenotype
KEGG: hsa:7225   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0006816 P:calcium ion transport
GO:0055085 P:transmembrane transport

References (10)

[1] “Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.”  Hofmann T.et.al.   9930701
[2] “Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22.”  D'Esposito M.et.al.   9925922
[3] “TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells.”  Philipp S.et.al.   10816590
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.”  Lussier M.P.et.al.   15757897
[6] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[7] “RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.”  Lussier M.P.et.al.   17850865
[8] “Phosphoproteome of resting human platelets.”  Zahedi R.P.et.al.   18088087
[9] “TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.”  Reiser J.et.al.   15924139
[10] “A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.”  Winn M.P.et.al.   15879175

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC YGYYPCFRGS 
61:	DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE RFLDAAEYGN IPVVRKMLEE 
121:	CHSLNVNCVD YMGQNALQLA VANEHLEITE LLLKKENLSR VGDALLLAIS KGYVRIVEAI 
181:	LSHPAFAEGK RLATSPSQSE LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR 
241:	KGARIERPHD YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 
301:	SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV ETLQSGDHGR 
361:	PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ QTMAVKFLVV LAVAIGLPFL 
421:	ALIYWFAPCS KMGKIMRGPF MKFVAHAASF TIFLGLLVMN AADRFEGTKL LPNETSTDNA 
481:	KQLFRMKTSC FSWMEMLIIS WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS 
541:	FIARFMAFWH ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA 
601:	IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI GMFNLYSYYI 
661:	GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI ENIGYVLYGV YNVTMVIVLL 
721:	NMLIAMINSS FQEIEDDADV EWKFARAKLW FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL 
781:	KKWISELFQG HKKGFQEDAE MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS 
841:	EDFHLNSFNN PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE 
901:	EKSQNTEDLA ELIRELGEKL SMEPNQEETN R