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1.A.4.1.6
Sperm TRP-3 (SPE-41) Ca2+-permeable channel. Translocated from vesicles to the plasma membrane upon sperm activation in a process dependent on the 4TMS SPE-38 protein (8.A.36.1.1) (Singaravelu et al., 2012) during sperm-egg interactions leading to fertilization (Xu et al., 2003).

Accession Number:Q21070
Protein Name:Putative uncharacterized protein spe-41 aka TRP3
Length:854
Molecular Weight:96937.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: KOG3609
HEGENOM: HBG382979
RefSeq: NP_497709.1   
Entrez Gene ID: 175446   
Pfam: PF00023    PF00520    PF08344   
KEGG: cel:K01A11.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.”  Xu X.Z.et.al.   12914694

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVGKEKKEST RLKLSAIKEY LGKYRGVDAD NNEGYDGHQK WHENDQVVLQ AMAYFYKAVK 
61:	SKLYSEVRSF LGILLPHGPD DGRLSSLQSL LMDTSSEESL KEALLLSIAV GSRPLVEFVL 
121:	VLFVDAPYLE RSGSANSPHF PPHMTPLMLA CILNNFSIVQ CLITRGHCIQ IPHFITCECK 
181:	TCKRETVTTH SSTRLVDVMR ALSSEAYLWL ATDDVFAATC AVARDLQQLA SDDQLEYVET 
241:	YRDLEMNVQR FLCRISDQAW RVDEFNMMVA NRNYCPERMT EISSPRLQMA MDSQMRQFTC 
301:	STNSQTTIKS VFRSDWYNYG IKPKRDAWRF LRACILMPFL VMLHAFMPTK GTTMCVPLAR 
361:	FIAHITMYLV FLIAAILRPT IGFYFAWTDS IEVTVQALEI FMYAYVMGLA LEKGILFYRV 
421:	GRDGFFAFWW RWFDAALIFI FLFSLIFFTG KWGKREAFDP SSVDRMHWPS FEFSLLHEIC 
481:	LAIACVLSIL KCFYYAQMMK SIGGSVISVG KCVGKTYTYI LIMVAIIVSF SVGLNIIVDP 
541:	YLNRSTMKIG DQDYTKTTDS YETIGTSSKN LFWSIFGYLG PSTFTTVVGN TGPNMDPVKH 
601:	TLNSSTFEIL AAVYHGILII TVLNLMTSIL VKGADEVLDN EEMEFKFTRA AIYSEFLSWE 
661:	MAAPPPLNLI LVVAHFVHRN LLKRYYASPA WGEKPANDDV EDQAADEQYM QLLMVVFARF 
721:	VASKECKYKS IWRSEFHREE KQPPRVTFLT TGAHSFLMDN TFEGFKMRSS RTMEAEGYKE 
781:	YTTVQYYVPK SKTPGPAAAA DAGTKVAPKD DKPQNNPVLA RTGIDSPVPS SKQVMSSELS 
841:	ASIPRARDVT FLGV