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1.A.4.2.10
TRPV5 epithelial Ca2+ channel (ECaCl) (forms homo- and heterotetrameric channels with TRPV6; requires the S100A10-annexin 2 complex for routing to the plasma membrane) (Hoenderop et al., 2003; van de Graaf et al., 2003).  The kidney maintains whole body calcium homoeostasis due to the reabsorption of Ca2+ filtered by the kidney glomerulus. TRPV5 regulates urinary Ca2+ excretion by mediating active Ca2+ reabsorption in the distal convoluted tubule of the kidney. The histidine kinase, nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca2+ flux, and this activation requires histidine 711 in the carboxy terminal tail of TRPV5. In addition, the histidine phosphatase, protein histidine phosphatase 1 (PHPT1), inhibits NDPK-B activated TRPV5 (Cai et al. 2014).  TRPV5 also transports cadmium (Cd2+). The L530R mutation is associated with recurrent kidney stones (Wang et al. 2017).

Accession Number:Q9NQA5
Protein Name:TRPV5
Length:729
Molecular Weight:82551.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate Cd2+, Ca2+

Cross database links:

Genevestigator: Q9NQA5
HEGENOM: HBG444402
RefSeq: NP_062815.2   
Entrez Gene ID: 56302   
Pfam: PF00023   
OMIM: 606679  gene
KEGG: hsa:56302   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0051262 P:protein tetramerization

References (3)

[1] “Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial calcium channel (ECAC1).”  Mueller D.et.al.   10945469
[2] “Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.”  Peng J.-B.et.al.   11549322
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGGFLPKAEG PGSQLQKLLP SFLVREQDWD QHLDKLHMLQ QKRILESPLL RASKENDLSV 
61:	LRQLLLDCTC DVRQRGALGE TALHIAALYD NLEAALVLME AAPELVFEPT TCEAFAGQTA 
121:	LHIAVVNQNV NLVRALLTRR ASVSARATGT AFRRSPRNLI YFGEHPLSFA ACVNSEEIVR 
181:	LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDGHGDHLQ PLDLVPNHQG 
241:	LTPFKLAGVE GNTVMFQHLM QKRRHIQWTY GPLTSILYDL TEIDSWGEEL SFLELVVSSD 
301:	KREARQILEQ TPVKELVSFK WNKYGRPYFC ILAALYLLYM ICFTTCCVYR PLKFRGGNRT 
361:	HSRDITILQQ KLLQEAYETR EDIIRLVGEL VSIVGAVIIL LLEIPDIFRV GASRYFGKTI 
421:	LGGPFHVIII TYASLVLVTM VMRLTNTNGE VVPMSFALVL GWCSVMYFTR GFQMLGPFTI 
481:	MIQKMIFGDL MRFCWLMAVV ILGFASAFYI IFQTEDPTSL GQFYDYPMAL FTTFELFLTV 
541:	IDAPANYDVD LPFMFSIVNF AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT 
601:	TVMLERKLPR CLWPRSGICG CEFGLGDRWF LRVENHNDQN PLRVLRYVEV FKNSDKEDDQ 
661:	EHPSEKQPSG AESGTLARAS LALPTSSLSR TASQSSSHRG WEILRQNTLG HLNLGLNLSE 
721:	GDGEEVYHF