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1.A.4.2.2
Stretch-inhibitable non-selective cation channel, SIC

Accession Number:Q9Z182
Protein Name:SIC
Length:528
Molecular Weight:61018.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: Q9Z182

Gene Ontology

GO:0005829 C:cytosol
GO:0030425 C:dendrite
GO:0043025 C:neuronal cell body
GO:0005886 C:plasma membrane
GO:0045202 C:synapse
GO:0005261 F:cation channel activity
GO:0017081 F:chloride channel regulator activity
GO:0005515 F:protein binding
GO:0006812 P:cation transport
GO:0071363 P:cellular response to growth factor stimulus
GO:0071502 P:cellular response to temperature stimulus
GO:0007204 P:elevation of cytosolic calcium ion concentr...
GO:0014047 P:glutamate secretion
GO:0001774 P:microglial cell activation
GO:0090212 P:negative regulation of establishment of blo...
GO:0043065 P:positive regulation of apoptosis
GO:0060454 P:positive regulation of gastric acid secretion
GO:0045429 P:positive regulation of nitric oxide biosynt...
GO:0043434 P:response to peptide hormone stimulus
GO:0009268 P:response to pH

References (1)

[1] “Cloning of a stretch-inhibitable nonselective cation channel.”  Suzuki M.et.al.   10037722

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYNEILILGA KLHPTLKLEE ITNRKGLTPL ALAASSGKIG VLAYILQREI HEPECRHLSR 
61:	KFTEWAYGAV HSSLYDLSCI DTCEKNSVLE VIAYSSSETP NRHDMLLVEP LNRLLQDKWD 
121:	RFVKRIFYFN FFVYCLYMII FTAAAYYRPV EGLPPYKLKN TVGDYFRVTG EILSVSGGVY 
181:	FFFRGIQYFL QRRPSLKSLF VDSYSEILFF VQSLFMLVSV VLYFSQRKEY VASMVFSLAM 
241:	GWTNMLYYTR GFQQMGIYAV MIEKMILRDL CRFMFVYLVF LFGFSTAVVT LIEDGKNNSL 
301:	PMESTPHKCR GSACKPGNSY NSLYSTCLEL FKFTIGMGDL EFTENYDFKA VFIILLLAYV 
361:	ILTYILLLNM LIALMGETVG QVSKESKHIW KLQWATTILD IERSFPVFLR KAFRSGEMVT 
421:	VGKSSDGTPD RRWCFRVDEV NWSHWNQNLG IINEDPGKSE IYQYYGFSHT MGRLRRDRWS 
481:	SVVPRVVELN KNSDTDEVVV PLDNLGNPNC DGHQQGYAPK WRAEDAPL