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1.A.4.2.3
Vitamin D-responsive, apical, epithelial Ca2+ channel, ECaC

Accession Number:Q9XSM3
Protein Name:ECaC
Length:730
Molecular Weight:82814.00
Species:Oryctolagus cuniculus (Rabbit) [9986]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: maNOG16273
DIP: DIP-46154N
RefSeq: NP_001076126.1   
Entrez Gene ID: 100009364   
Pfam: PF00023    PF00520   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport
GO:0051262 P:protein tetramerization
GO:0055085 P:transmembrane transport

References (4)

[1] “Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia.”  Hoenderop J.G.J.et.al.   10085067
[2] “The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel.”  Nilius B.et.al.   11035011
[3] “Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.”  Hoenderop J.G.et.al.   12574114
[4] “The carboxyl terminus of the epithelial Ca(2+) channel ECaC1 is involved in Ca(2+)-dependent inactivation.”  Nilius B.et.al.   12634930

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGACPPKAKG PWAQLQKLLI SWPVGEQDWE QYRDRVNMLQ QERIRDSPLL QAAKENDLRL 
61:	LKILLLNQSC DFQQRGAVGE TALHVAALYD NLEAATLLME AAPELAKEPA LCEPFVGQTA 
121:	LHIAVMNQNL NLVRALLARG ASVSARATGA AFRRSPHNLI YYGEHPLSFA ACVGSEEIVR 
181:	LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDEHSDHLQ SLELVPNHQG 
241:	LTPFKLAGVE GNTVMFQHLM QKRKHVQWTC GPLTSTLYDL TEIDSWGEEL SFLELVVSSK 
301:	KREARQILEQ TPVKELVSFK WKKYGRPYFC VLASLYILYM ICFTTCCIYR PLKLRDDNRT 
361:	DPRDITILQQ KLLQEAYVTH QDNIRLVGEL VTVTGAVIIL LLEIPDIFRV GASRYFGQTI 
421:	LGGPFHVIII TYASLVLLTM VMRLTNMNGE VVPLSFALVL GWCSVMYFAR GFQMLGPFTI 
481:	MIQKMIFGDL MRFCWLMAVV ILGFASAFHI TFQTEDPNNL GEFSDYPTAL FSTFELFLTI 
541:	IDGPANYSVD LPFMYCITYA AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT 
601:	TVMLERKMPR FLWPRSGICG YEYGLGDRWF LRVENHHDQN PLRVLRYVEA FKCSDKEDGQ 
661:	EQLSEKRPST VESGMLSRAS VAFQTPSLSR TTSQSSNSHR GWEILRRNTL GHLNLGLDLG 
721:	EGDGEEVYHF