TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.4.2.4
Insulin-like growth factor I-regulated Ca2+ channel

Accession Number:Q9WTR1
Protein Name:TRPV2 aka VRL1 aka GRC
Length:756
Molecular Weight:85965.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q9WTR1
eggNOG: roNOG05625
HEGENOM: HBG446456
RefSeq: NP_035836.2   
Entrez Gene ID: 22368   
KEGG: mmu:22368   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042470 C:melanosome
GO:0005886 C:plasma membrane
GO:0005262 F:calcium channel activity
GO:0006816 P:calcium ion transport

References (7)

[1] “Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I.”  Kanzaki M.et.al.   10559903
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.”  Boels K.et.al.   11707512
[6] “Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.”  Zanivan S.et.al.   19367708
[7] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTSASNPPAF RLETSDGDEE GSAEVNKGKN EPPPMESPFQ GEDRNFSPQI KVNLNYRKGL 
61:	GPSQQDPNRF DRDRLFSVVS RGVPEELTGL LEYLRRTSKY LTDSAYTEGS TGKTCLMKAV 
121:	LNLQDGVNAC ILPLLQIDRD SGNPQPLVNA QCTDEFYRGH SALHIAIEKR SLWCVKLLVE 
181:	NGANVHIRAC GRFFQKHQGT CFYFGELPLS LAACTKQWDV VTYLLENPHQ PASLEATDSL 
241:	GNTVLHALVM IADNSPENSA LVIHMYDSLL QMGARLCPTV QLEDICNHQG LTPLKLAAKE 
301:	GKIEIFRHIL QREFSGLYQP LSRKFTEWCY GPVRVSLYDL SSVDSWEKNS VLEIIAFHCK 
361:	SPHRHRMVVL EPLNKLLQEK WDRLIPRFFF NFACYLVYMI IFTIVAYHQP SLEQPAIPSS 
421:	KATFGDSMLL LGHILILLGG IYLLLGQLWY FWRRRLFIWI SFMDSYFEIL FLVQALLTVL 
481:	SQVLRFVETE WYLPLLVSSL VLGWLNLLYY TRGFQHTGIY SVMIQKVILR DLLRFLLVYL 
541:	VFLFGFAVAL VSLSREARSP KAPEDSNTTV TEKPTLGQEE EPVPYGGILD ASLELFKFTI 
601:	GMGELAFQEQ LRFRGVVLLL LLAYVLLTYV LLLNMLIALM SETVNSVATD SWSIWKLQKA 
661:	ISVLEMENGY WWCRRKRHRA GRLLKVGTKG DGIPDERWCF RVEEVNWAAW EKTLPTLSED 
721:	PSGAGITGYK KNPTSKPGKN SASEEDHLPL QVLQSH