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1.A.4.2.7
Intestinal endocyte Ca2+ (Sr2+; Ba2+) entry channel, CaT1. Excision of the Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility as does the single D541A pore mutation (Weissgerber et al., 2012).

Accession Number:Q9R186
Protein Name:CaT1
Length:727
Molecular Weight:83236.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Sr2+, Ca2+, Ba2+

Cross database links:

Genevestigator: Q9R186
eggNOG: roNOG09732
RefSeq: NP_446138.1   
Entrez Gene ID: 114246   
Pfam: PF00023    PF00520   
KEGG: rno:114246   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005227 F:calcium activated cation channel activity
GO:0005262 F:calcium channel activity
GO:0005516 F:calmodulin binding
GO:0006816 P:calcium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption.”  Peng J.-B.et.al.   10428857
[2] “CaT1 manifests the pore properties of the calcium-release-activated calcium channel.”  Yue L.et.al.   11287959
Structure:
5iwk     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGWSLPKEKG LILCLWNKFC RWFHRRESWA QSRDEQNLLQ QKRIWESPLL LAAKENNVQA 
61:	LIKLLKFEGC EVHQKGAMGE TALHIAALYD NLEAAMVLME AAPELVFEPM TSELYEGQTA 
121:	LHIAVINQNV NLVRALLARG ASVSARATGS VFHYRPHNLI YYGEHPLSFA ACVGSEEIVR 
181:	LLIEHGADIR AQDSLGNTVL HILILQPNKT FACQMYNLLL SYDGGDHLKS LELVPNNQGL 
241:	TPFKLAGVEG NIVMFQHLMQ KRKHIQWTYG PLTSTLYDLT EIDSSGDDQS LLELIVTTKK 
301:	REARQILDQT PVKELVSLKW KRYGRPYFCV LGAIYVLYII CFTMCCVYRP LKPRITNRTN 
361:	PRDNTLLQQK LLQEAYVTPK DDLRLVGELV SIVGAVIILL VEIPDIFRLG VTRFFGQTIL 
421:	GGPFHVIIVT YAFMVLVTMV MRLTNSDGEV VPMSFALVLG WCNVMYFARG FQMLGPFTIM 
481:	IQKMIFGDLM RFCWLMAVVI LGFASAFYII FQTEDPDELG HFYDYPMALF STFELFLTII 
541:	DGPANYDVDL PFMYSITYAA FAIIATLLML NLLIAMMGDT HWRVAHERDE LWRAQVVATT 
601:	VMLERKLPRC LWPRSGICGR EYGLGDRWFL RVEDRQDLNR QRIRRYAQAF QQQDDLYSED 
661:	LEKDSGEKLE MARPFGAYLS FPTPSVSRST SRSSTNWDRL RQGALRKDLQ GIINRGLEDG 
721:	EGWEYQI