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1.A.4.3.1
Olfactory, mechanosensitive channel. Forms a complex with Stim1 and Orai1 (TC# 1.A.52.1.1) which is required for SOC currents (Cheng et al., 2008) (most similar to 1.A.4.8.1, but both are most closely related to 1.A.4.2).  Serves as a chemo-, osmo- and touch sensation receptor (Xiao and Xu 2009).

Accession Number:O17469
Protein Name:OSM-9 aka B0212.5
Length:937
Molecular Weight:106848.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: meNOG07702
HEGENOM: HBG384787
RefSeq: NP_500372.1   
Entrez Gene ID: 177117   
Pfam: PF00023    PF00520   
KEGG: cel:B0212.5   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans.”  Colbert H.A.et.al.   9334401
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGGGSSRNKT EPRGEGVKLA FDPDEKWSNL YREREKNHLY KWVAVRKGGE LINIYERDGE 
61:	EGVLKFAEEK LLTILYDEGQ NPKLVTYSDY IKWKKGVNVQ LGLSEESVDM QQSRFKEHYA 
121:	LWKLNKRGVE GENLIHLLLN REQQVCYEIA RILLKRFPGM ANDIYLGDEQ FGQSALHLAI 
181:	VHDDYETVSL LLNSKADVNA RACGNFFLPE DFKLTNKITD YQGYAYYGEY PLAFAACFGN 
241:	KDIYDLLIQF GANPNLQDSF GNTILHMCVI NYSSSMYSYA VRHWAKPADP HVVNHAGFTP 
301:	LTLATKLGRK QIFEEMLEIM KVEFWRFSDM TCSAYPLNTL DTIQPDGSTN YDSALMTVIN 
361:	GSTPEHLDMI GSEVIQRLLA DKWKAFAQRK LIERLVLLIV QLITLSIVVY IRPTELPRLY 
421:	MEDPQWDDYI RTACELLTIL NCIFFVGYQQ LGEIRTQGMR GYLRNLKTAP AKAVFCIANL 
481:	FLLLCIPFRL MKKHEIEEAL FVFALPGSWI FLLFFARSAK LTGPFVQMIY SMIAGDMIRF 
541:	AIISAIFLVS FSQVFYFVGK DMDAKQKLED TNPHACRISG YTIYTYNTFP ETFITLFRAS 
601:	MGGYDYEEFS CANYQALTKT LFVLYMFVMP IMMINILIAM MGNTYTTVIA QAEKAWRQQY 
661:	AQIVMVLERS VGKERLAASQ LEYSIRLDQE GSSGMEVRGL MVIKQTKKTR ARQRKQAIYN 
721:	WKTIGRKVIH TIDKVGTEQA VLLLHGHDRL DRVYEDHVQP EKVPSRSRTP TRIGTTLNSS 
781:	KRLKTTTMVV GAAVTNTHEV RTDEAVNSML LSAPPSLSGE GATMDWQPSI TPVEERSESK 
841:	SQEDRSEAST PNLGIHRTTP KADSPIRVVE YSRTIRVRAA DTIPSIELPN IPTKQTSSTP 
901:	PHRAVSPRLR ADMFRRHQQP ASFDQSPPLP PTNDKSE