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1.A.4.3.2
The Nanchung (Nan) hearing ion channel; mediates hypo-osmotically activated Ca2+ influx in chordotonal neurons of insects (Kim et al., 2003). Nanchung is the "dry" humidity receptor, one of two hygrosensation receptors. These two transient receptor potential channels are needed for sensing humidity.  The other is Water witch (Wtrw), involved in detecting moist air. Neurons associated with specialized sensory hairs in the third segment of the antenna express these channels, and neurons expressing Wtrw and Nan project to central nervous system regions associated with mechanosensation. Construction of the hygrosensing system with opposing receptors may allow an organism to very sensitively detect changes in environmental humidity (Liu et al. 2007).

Accession Number:Q9VUD5
Protein Name:Nan aka CG5842-PA
Length:833
Molecular Weight:96196.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: inNOG05688
DIP: DIP-46202N
RefSeq: NP_648696.2   
Entrez Gene ID: 39571   
Pfam: PF00520   
KEGG: dme:Dmel_CG5842   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0009270 P:response to humidity
GO:0007605 P:sensory perception of sound
GO:0055085 P:transmembrane transport

References (3)

[1] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “A TRPV family ion channel required for hearing in Drosophila.”  Kim J.et.al.   12819662

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNTESNVTS GVKKQAGVST QALYKFVNLK GGGLLVDMMK RACQTKQFAE IDHAIKTKVE 
61:	PFLYNKGAGR YFPISKLVLL RNRDRPRTRQ LPEIRALENP DDDFNIHDYC PEVSEAEYIS 
121:	NPTAYRFVCW DLNMRGAVGE TILHLCLLNA SSLHADLAKR LLKFYPKLIL DIYMSDEYYG 
181:	ESVLHIAIVN EDPAMVKYLL DANADVQERC CGAFMSAEDT KFSRTDSPDH EYVALCPMTN 
241:	YDGYVYWGEY PLSFAACLSQ EECFRLVLAR GADPDFQDTN GNTVLHMLVI YEKIEMFDVG 
301:	YEVGTNIHIK NIQNLTPLTL AAKLGRVEMF FHVMSIEREI YWQLGSITCA AYPLLMIDTI 
361:	NEETGNINKD SVLNFVVFGD KLEHLELLDG VVIDLLKTKW DTFCKSRFYK QFYMFALYFL 
421:	ISLFSFILRP GPDAKDEDED GANSTTAKSD LYRQNGSDSY HLHSKRATMT TEYKTFWLNF 
481:	TEYYDPSEVE VLPAWWESYA QCPLMNLESD LAKLRIMAEL LNFVGAILYL LVALREARFL 
541:	GLKMFIENLM TAPSRVMFLF SCALMMTIPW LRVSCLTEID DHVTVVIMLT TAPYFLFFCR 
601:	GFKTVGPFVV MIYRMVMGDL LRFVSIYLVF VMGFSQAFYI IFLTFDNPSS PEDQDAESNP 
661:	MPSPMESIVA MFLMSLTNFG DYYGAMVSTQ HEYEAKILFF LFMVIVSVLL VNMLIAMMGN 
721:	TYQKIAEIRN EWQRQWARIV LVVERSVPPA ERLKNFMQYS QSMSDGRRAL VLRLNMTEEK 
781:	EEMKEVQEMK RIHQRFAKKR QMEREARALR RQQEYEKFFG TAPKSECSDN NNF