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1.A.4.5.4
Ca2+-activated nonselective cation (Na+ and K+) channel (non-permeable to Ca2+), TRPM4b. Forms a protein-protein interaction with the TRPC3 channel and suppresses store-operated Ca+ entry (Park et al., 2008).  Contributes to the mammalian atrial action potential (Simard et al. 2013).

Accession Number:Q8TD43
Protein Name:TRPM4B
Length:1214
Molecular Weight:134301.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, K+

Cross database links:

Genevestigator: Q8TD43
HEGENOM: HBG443937
RefSeq: NP_060106.2   
Entrez Gene ID: 54795   
Pfam: PF00520   
OMIM: 606936  gene
KEGG: hsa:54795   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005516 F:calmodulin binding
GO:0006955 P:immune response
GO:0055085 P:transmembrane transport

References (18)

[1] “Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.”  Xu X.-Z.S.et.al.   11535825
[2] “TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.”  Launay P.et.al.   12015988
[3] “TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.”  Hofmann T.et.al.   12842017
[4] “Voltage dependence of the Ca2+-activated cation channel TRPM4.”  Nilius B.et.al.   12799367
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.”  Earley S.et.al.   15472118
[8] “Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes.”  Guinamard R.et.al.   15121803
[9] “Decavanadate modulates gating of TRPM4 cation channels.”  Nilius B.et.al.   15331675
[10] “Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b.”  Nilius B.et.al.   14758478
[11] “TRPM4 regulates calcium oscillations after T cell activation.”  Launay P.et.al.   15550671
[12] “Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.”  Nilius B.et.al.   15590641
[13] “The selectivity filter of the cation channel TRPM4.”  Nilius B.et.al.   15845551
[14] “Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization.”  Zhang Z.et.al.   16186107
[15] “TRPM4 controls insulin secretion in pancreatic beta-cells.”  Cheng H.et.al.   16806463
[16] “The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate.”  Nilius B.et.al.   16424899
[17] “Tissue distribution profiles of the human TRPM cation channel family.”  Fonfria E.et.al.   16777713
[18] “A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.”  Takezawa R.et.al.   16407466

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVVPEKEQSW IPKIFKKKTC TTFIVDSTDP GGTLCQCGRP RTAHPAVAME DAFGAAVVTV 
61:	WDSDAHTTEK PTDAYGELDF TGAGRKHSNF LRLSDRTDPA AVYSLVTRTW GFRAPNLVVS 
121:	VLGGSGGPVL QTWLQDLLRR GLVRAAQSTG AWIVTGGLHT GIGRHVGVAV RDHQMASTGG 
181:	TKVVAMGVAP WGVVRNRDTL INPKGSFPAR YRWRGDPEDG VQFPLDYNYS AFFLVDDGTH 
241:	GCLGGENRFR LRLESYISQQ KTGVGGTGID IPVLLLLIDG DEKMLTRIEN ATQAQLPCLL 
301:	VAGSGGAADC LAETLEDTLA PGSGGARQGE ARDRIRRFFP KGDLEVLQAQ VERIMTRKEL 
361:	LTVYSSEDGS EEFETIVLKA LVKACGSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIQW 
421:	RSFHLEASLM DALLNDRPEF VRLLISHGLS LGHFLTPMRL AQLYSAAPSN SLIRNLLDQA 
481:	SHSAGTKAPA LKGGAAELRP PDVGHVLRML LGKMCAPRYP SGGAWDPHPG QGFGESMYLL 
541:	SDKATSPLSL DAGLGQAPWS DLLLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA 
601:	RLEPDAEEAA RRKDLAFKFE GMGVDLFGEC YRSSEVRAAR LLLRRCPLWG DATCLQLAMQ 
661:	ADARAFFAQD GVQSLLTQKW WGDMASTTPI WALVLAFFCP PLIYTRLITF RKSEEEPTRE 
721:	ELEFDMDSVI NGEGPVGTAD PAEKTPLGVP RQSGRPGCCG GRCGGRRCLR RWFHFWGAPV 
781:	TIFMGNVVSY LLFLLLFSRV LLVDFQPAPP GSLELLLYFW AFTLLCEELR QGLSGGGGSL 
841:	ASGGPGPGHA SLSQRLRLYL ADSWNQCDLV ALTCFLLGVG CRLTPGLYHL GRTVLCIDFM 
901:	VFTVRLLHIF TVNKQLGPKI VIVSKMMKDV FFFLFFLGVW LVAYGVATEG LLRPRDSDFP 
961:	SILRRVFYRP YLQIFGQIPQ EDMDVALMEH SNCSSEPGFW AHPPGAQAGT CVSQYANWLV 
1021:	VLLLVIFLLV ANILLVNLLI AMFSYTFGKV QGNSDLYWKA QRYRLIREFH SRPALAPPFI 
1081:	VISHLRLLLR QLCRRPRSPQ PSSPALEHFR VYLSKEAERK LLTWESVHKE NFLLARARDK 
1141:	RESDSERLKR TSQKVDLALK QLGHIREYEQ RLKVLEREVQ QCSRVLGWVA EALSRSALLP 
1201:	PGGPPPPDLP GSKD