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1.A.4.5.9
Transient receptor potential cation channel TrpM

Accession Number:A8DYE2
Protein Name:Transient receptor potential cation channel trpm
Length:2023
Molecular Weight:225538.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: NOG253824
Entrez Gene ID: 36694   
Pfam: PF00520   
KEGG: dme:Dmel_CG3412   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0046873 F:metal ion transmembrane transporter activity
GO:0016049 P:cell growth
GO:0070838 P:divalent metal ion transport
GO:0010960 P:magnesium ion homeostasis
GO:0007005 P:mitochondrion organization
GO:0055069 P:zinc ion homeostasis

References (5)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[4] “RNA editing in Drosophila melanogaster: new targets and functional consequences.”  Stapleton M.et.al.   17018572
[5] “Phosphoproteome analysis of Drosophila melanogaster embryos.”  Zhai B.et.al.   18327897

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVVTDSPLAP HKYVRRISKD FSTVRRYSNT PAVVVGSFRA STSAFIAAES AAHLPTCSSP 
61:	TTRTPVSTPR GIRRRQRMRK RSSVSSTLSK VLILNVRDLL KAHAGSEPLK EHQPRSWIET 
121:	NFQKRECIKF IPCPKDDTKC CCGQAQITHQ TIPGIESGSP GDLWLPTKHT RPQPTDAYGT 
181:	IEFQGGAHPT KAQYVRLSFD TRPELLVQLF TKEWNLELPK LLITVQGGKA NFDLQAKLKK 
241:	EIRKGLLKAA KTTGAWIFTG GTNTGVTKQV GDALLLEGQQ RTGRVVSIGI APWGIVERNH 
301:	ELLGHNREVP CHSISSPRSK LAVLNNRHAY FLLVDNGTQA KYGAELILRR KLEKFISNLK 
361:	LHPFTHSSTP VVCLVIEGGT NTIRAVLEYV TDSPPVPVVV CDGSGRAADL LAFVHKYASD 
421:	GEEQPVLESM RDYLIGTIQK TFEVGLDQSE KLYQELLQCT RNKNLITVFR IQEKPEGEAQ 
481:	ELDQTILTAL FKSQHLSPPE QLSLALTWNR VDIARSEIFV YGQEWPNGAL DEAMMQALEH 
541:	DRIDFVKLLL ENGVSMKKFL TIPRLEELYN TKHGPANTLG YILRDVRPHI PKGYIYTLHD 
601:	IGLVINKLMG GAYRSYYTRR KFRPIYAKVM NSYANACRKS STYQYQRYAG ANSLSLVTGL 
661:	LPFTSEMALF EFPFNELLIW AVLTKRQQMA LLMWTHGEEA LAKSLVSCKL YKAMAHEAAE 
721:	DDLDTEIYEE LRSYAKEFES KGNKLLDFSY RQDAEKAQRL LTCELHSWSN QSCLSLAVAA 
781:	NHRALLAHPC SQVILADLWM GGLRTRKNTN FKVILGLAMP FYIRQLDFKS KEELQQMPQT 
841:	EEEHLENQNL DNDDSDRSQP DAEALLADTY SVRDTKVHEN GKVSLTDSDT AQFREFFNLS 
901:	EYNEVKQHQP LRLKKKFYEF YTAPITKFWA DSIAYMFFLI MFSFTVLVKM EQMPRWQEWY 
961:	SIAYITTLGF EKVREIISSE PVAITHKFSV WAWNMWNPCD GAAIILFVIG LAFRFRENTM 
1021:	DIGRVIYCVD SIYWYLRILN ILGVNKYLGP LVTMMGKMVK NMIYFVVLLA VVLMSFGVSR 
1081:	QAILYPNKQP TWSLIKEVTF QPYFMLYGEV FAGDIDPPCG EDPSQPGCVT GHWVTPITMS 
1141:	MYLLIANILL INLLIAVFNN IFNEVNSVSH QVWMFQRFTV VMEYQQKPVL PPPFIALCHF 
1201:	YSLLKYCVRK AKGLEVQRDN GLKLFLEKDD LERLYDFEEE CVEGFFHEQE IILNQSTDER 
1261:	VKNTTERVET MSQKIEDINQ KENIQTATVQ NIEFRLRKME ESSEQILSHL AVIHRFMSTH 
1321:	TAGADDLRGS TINIPGEMQR MRTISISDTE GGSGPGGNGG GGGGGGAIVP LGLGAGLNLN 
1381:	SLQVTTRRRF NRSLTEVRPD AYIFDEGTHF EVVPLPEEPD EVVKSREALN EQVVRKASMQ 
1441:	SEADSDIYIP VSQRPSTCET VKRTPYVTVR QDTGASTESK DTLTPMGNND DDQTLVGGDN 
1501:	SDDATPDINF EAARHRALRQ RTVSLCRRNS ETYSLTGADI NRSHISLNQL ASLSRRQMSL 
1561:	TQSEPDSDKD APIAQGSAHP GKSVLHAKPS RNILLKLHSE YTSITDELES VCHMIASPTV 
1621:	SLPSNKASLD RPKTEMSRAE AAALLEKKHL KECEENDYMI LEGLIESRGS IDASAQGFEI 
1681:	GVSIDYSHRY PLRRETAVEL SPSKPSVDGD LMGGGEGGGA GGGDSSDTSG AGSCGAMVGI 
1741:	SSGFQLKNER PWQRNSSMEQ QTYPSPLVPT RATSDFLNPP YEGRLFKKSS ESLQKNSSTE 
1801:	TDYSAHPYRF IKQSSNETNT SLTGSYNVDT PSLTAEPSLD AGDSHSATGI SISVGAVGGT 
1861:	ATARYQPIRT ASVGAADGRR LREESSSSLD LSSSGPVTMQ AAPAPPVRPM LLKKQFSVDQ 
1921:	GKPSQTAAEA VPQTPEAAQA GQAKLISTLK PQPFASKLGM NVLKESSSST DESVGSSAKS 
1981:	SNPALSIPQI STHLVQDEIA KLSSNIKSST ESEKDPPFNE TMC