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1.A.4.6.2
Warm-activated thermosensory cation channel of insects, ANKTM1 or TrpA1 (Viswanath et al., 2003). It is required to control activity during the warm part of the day (Roessingh et al. 2015). The TrpA1(A) transcript spliced with exon10b (TrpA1(A)10b) that is present in a subset of midgut enteroendocrine cells (EECs) is critical for uracil-dependent defecation of microorganisms (Du et al. 2016).

Accession Number:Q7Z020
Protein Name:Transient receptor potential cation channel subfamily A member 1 aka ANKTM1
Length:1296
Molecular Weight:145971.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: inNOG08973
RefSeq: NP_001097554.3    NP_648263.4   
Entrez Gene ID: 39015   
Pfam: PF00023    PF00520   
KEGG: dme:Dmel_CG5751   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005261 F:cation channel activity
GO:0006812 P:cation transport
GO:0034605 P:cellular response to heat
GO:0043052 P:thermotaxis
GO:0055085 P:transmembrane transport

References (4)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “Ion channels: opposite thermosensor in fruitfly and mouse.”  Viswanath V.et.al.   12815418
[4] “The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.”  Rosenzweig M.et.al.   15681611

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKLYNGVYS GQCGALSPPD LMEAQPKLLP KPRSNSSGST GRNSKYWIFS MIIERSAGPK 
61:	RIEIDGDDAD TPLEAILPAE PPAEVCLLRD SPFRILRSTM TSGDKETPKR EDFASALRFL 
121:	MGGCAREPEM TAMAPLNLPK KWARILRMSS TPKIPIVDYL EAAESGNLDD FKRLFMADNS 
181:	RIALKDAKGR TAAHQAAARN RVNILRYIRD QNGDFNAKDN AGNTPLHIAV ESDAYDALDY 
241:	LLSIPVDTGV LNEKKQAPVH LATELNKVKS LRVMGQYRNV IDIQQGGEHG RTALHLAAIY 
301:	DHEECARILI TEFDACPRKP CNNGYYPIHE AAKNASSKTM EVFFQWGEQR GCTREEMISF 
361:	YDSEGNVPLH SAVHGGDIKA VELCLKSGAK ISTQQHDLST PVHLACAQGA IDIVKLMFEM 
421:	QPMEKRLCLS CTDVQKMTPL HCASMFDHPD IVSYLVAEGA DINALDKEHR SPLLLAASRS 
481:	GWKTVHLLIR LGACISVKDA AARNVLHFVI MNGGRLTDFA EQVANCQTQA QLKLLLNEKD 
541:	SMGCSPLHYA SRDGHIRSLE NLIRLGACIN LKNNNNESPL HFAARYGRYN TVRQLLDSEK 
601:	GSFIINESDG AGMTPLHISS QQGHTRVVQL LLNRGALLHR DHTGRNPLQL AAMSGYTETI 
661:	ELLHSVHSHL LDQVDKDGNT ALHLATMENK PHAISVLMSM GCKLVYNVLD MSAIDYAIYY 
721:	KYPEAALAMV THEERANEVM ALRSDKHPCV TLALIASMPK VFEAVQDKCI TKANCKKDSK 
781:	SFYIKYSFAF LQCPFMFAKI DEKTGESITT ASPIPLPALN TMVTHGRVEL LAHPLSQKYL 
841:	QMKWNSYGKY FHLANLLIYS IFLVFVTIYS SLMMNNIELK AGDNKTMSQY CNMGWEQLTM 
901:	NLSQNPSVAS QIRLDSCEER INRTTAILFC AVVIVVYILL NSMRELIQIY QQKLHYILET 
961:	VNLISWVLYI SALVMVTPAF QPDGGINTIH YSAASIAVFL SWFRLLLFLQ RFDQVGIYVV 
1021:	MFLEILQTLI KVLMVFSILI IAFGLAFYIL LSKIIDPQPN HLSFSNIPMS LLRTFSMMLG 
1081:	ELDFVGTYVN TYYRDQLKVP MTSFLILSVF MILMPILLMN LLIGLAVGDI ESVRRNAQLK 
1141:	RLAMQVVLHT ELERKLPHVW LQRVDKMELI EYPNETKCKL GFCDFILRKW FSNPFTEDSS 
1201:	MDVISFDNND DYINAELERQ RRKLRDISRM LEQQHHLVRL IVQKMEIKTE ADDVDEGISP 
1261:	NELRSVVGLR SAGGNRWNSP RVRNKLRAAL SFNKSM