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1.A.4.6.4
The Pyrexia (Pyx) thermal TRP channel allowing increased tolerance to high temperature (Lee et al., 2005)

Accession Number:Q9W0T5
Protein Name:Transient receptor potential channel pyrexia aka pyx
Length:956
Molecular Weight:107920.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

eggNOG: inNOG07340
RefSeq: NP_612015.1    NP_728501.1   
Entrez Gene ID: 38037   
Pfam: PF00023    PF00520   
KEGG: dme:Dmel_CG1714   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005261 F:cation channel activity
GO:0006812 P:cation transport
GO:0051290 P:protein heterotetramerization
GO:0009408 P:response to heat
GO:0055085 P:transmembrane transport

References (4)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[4] “Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster.”  Lee Y.et.al.   15731759

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENVRFSIIE NDLKWNSESD PTADVDLLLD KRSISSEANS AGVFSDEAHE IFARQQQNQI 
61:	LWDLDEVKET LTESPGGKHV VDMVQSGCFL ELMTDSADCN LALICCSVFG SVENTLFLLK 
121:	HYNADPNVAD SRGRTPLHFA CCRANAPIAK VLLDFGADPN RWDARKEVTS LHCAASSKSV 
181:	ECILLLLRRK ASINIGIEKR SALHYAIDVN AVDCVEILLK YGADPNTPQV YTETPLHTAS 
241:	AAGFAKCVQL LLSHNADVRS QFGEGKVTAL HLAAENDYVE CARLLLEHRA EVDCRNASHQ 
301:	TPLHLACLSQ SIGTVDLLIS YGANVNAVYR DGRTALHAAI VKQSRSLDCC NALLKAGADV 
361:	NKADNYGYTP LHIAALNEFS SCVYTFIEHG ADITARTDGR VSALSFIVRR TPEIIPKLMQ 
421:	KLDSSIKAND QEIGDVDCQI KLDFRLLVPS SSMDRGETEL LLSLIEVGQK RILMHPLCET 
481:	FLFLKWRRIR KFFLMSLAYH TLFVILFTFY VIWVYVRCCK KEELCVAPGY VSTIGYLVII 
541:	LNLILLGKEV FQMAHGLRGY AKYWENWLQW TIGTGVLLCV TPETVRTDDL TAVPVWQHHV 
601:	AAIVILLVWL ELMMLVGRFP IFGVYVQMFT KVAVNFAKFL LAYICLLVAF GLSFAVLFND 
661:	YPAFENITWS FLKSITMMSG ELEFEDIFYG DYAVKFPVTA HIIFLSFVLL VTVILTNLMV 
721:	GLAVSDIQGL QVSATLDRLV RQAELVSRLE SLFFSRLLRS APTNLIQLCK RSALLRTSRD 
781:	KLQFTIRPND PRDNQLPEDI KLNVYKLVAE RRDRNQSLRR RQFENNYNIF SRSLQRQQQP 
841:	LHTDFLKPEP ATGTTKKTPQ NLFHMHELLR PRSATNVPQQ FRQEAEGTVQ MKNQANVLSA 
901:	VLAEVQAIKT QLVDLVAKFE RFSENATRKL NYSTDELCRL RQQGQSVASS HIRRHR