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1.A.4.6.5
Thermosensitive TPR channel TRPA1 (TrpA-1) of 1211 aas.  Detects a temperature drop promoting increased longevity.  This requires TPRA1-mediated Ca2+ influx and activation of protein kinase C.  Human TRPA1 (TC# 1.A.4.6.3) can functionally substitute for worm TRPA-1 in promoting longevity (Xiao et al. 2013).  Also mediates touch sensation.

Accession Number:Q18297
Protein Name:Transient receptor potential cation channel subfamily A member 1 homolog
Length:1211
Molecular Weight:138450.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL RSIIHQSARE 
61:	GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV KLLLSKNALP NTKNREGDTP 
121:	LHIASKYIYG YSDICSIIDE DQADSARKYN TATKKIINAL VSENAEIDPV NKYQLTPLHY 
181:	AAMKSNFSAL HALIKLKADV DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL 
241:	NTVFHIVALR GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM 
301:	EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH VAAQMNQLEV 
361:	VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA KKANLTITDK DERTPVFIGA 
421:	KFNALSSVEY ILDHLRKKNK ETERSALKSP TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI 
481:	VASNGYLEMM QLLQKHGASI TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM 
541:	GNSALHLAAR SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI 
601:	ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND HKDVARAFLE 
661:	TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE LASFVMDNCI EKSKEETDST 
721:	QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP 
781:	LKLMADAEKL HLLNHPLSKA LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN 
841:	VWNEESYYDS EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN 
901:	WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL FMIRKMPRFG 
961:	IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE FSTIFMSPLK TTVMMIGEFE 
1021:	FTGIFHGDET THAEKMFGPA HTAVACALFF FFCIIMTILL MNLLVGLAVD DIKGVQEKAE 
1081:	LKRLAMQVDL VLQIEASLHF FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS 
1141:	VSTDPEIDEM YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL 
1201:	NINIELEEKD N